Al-Dhaheri Rawya S, Douglas L Julia
Division of Infection and Immunity, Faculty of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow, G12 8QQ, United Kingdom.
Antimicrob Agents Chemother. 2008 May;52(5):1884-7. doi: 10.1128/AAC.01473-07. Epub 2008 Feb 19.
Biofilms and planktonic cells of five Candida species were surveyed for the presence of persister (drug-tolerant) cell populations after exposure to amphotericin B. None of the planktonic cultures (exponential or stationary phase) contained persister cells. However, persisters were found in biofilms of one of two strains of Candida albicans tested and in biofilms of Candida krusei and Candida parapsilosis, but not in biofilms of Candida glabrata or Candida tropicalis. These results suggest that persister cells cannot solely account for drug resistance in Candida biofilms.
研究了五种念珠菌的生物膜和浮游细胞在暴露于两性霉素B后是否存在持留菌（耐药）细胞群体。所有浮游培养物（指数期或稳定期）均未含有持留菌细胞。然而，在所测试的两株白色念珠菌中的一株的生物膜以及克鲁斯念珠菌和近平滑念珠菌的生物膜中发现了持留菌，但在光滑念珠菌或热带念珠菌的生物膜中未发现。这些结果表明，持留菌细胞不能单独解释念珠菌生物膜中的耐药性。
