某些念珠菌属生物膜中不存在对两性霉素B耐受的持留菌细胞。
Absence of amphotericin B-tolerant persister cells in biofilms of some Candida species.
作者信息
Al-Dhaheri Rawya S, Douglas L Julia
机构信息
Division of Infection and Immunity, Faculty of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow, G12 8QQ, United Kingdom.
出版信息
Antimicrob Agents Chemother. 2008 May;52(5):1884-7. doi: 10.1128/AAC.01473-07. Epub 2008 Feb 19.
Abstract
Biofilms and planktonic cells of five Candida species were surveyed for the presence of persister (drug-tolerant) cell populations after exposure to amphotericin B. None of the planktonic cultures (exponential or stationary phase) contained persister cells. However, persisters were found in biofilms of one of two strains of Candida albicans tested and in biofilms of Candida krusei and Candida parapsilosis, but not in biofilms of Candida glabrata or Candida tropicalis. These results suggest that persister cells cannot solely account for drug resistance in Candida biofilms.
摘要
研究了五种念珠菌的生物膜和浮游细胞在暴露于两性霉素B后是否存在持留菌（耐药）细胞群体。所有浮游培养物（指数期或稳定期）均未含有持留菌细胞。然而，在所测试的两株白色念珠菌中的一株的生物膜以及克鲁斯念珠菌和近平滑念珠菌的生物膜中发现了持留菌，但在光滑念珠菌或热带念珠菌的生物膜中未发现。这些结果表明，持留菌细胞不能单独解释念珠菌生物膜中的耐药性。
相似文献
1
Absence of amphotericin B-tolerant persister cells in biofilms of some Candida species.
Antimicrob Agents Chemother. 2008 May;52(5):1884-7. doi: 10.1128/AAC.01473-07. Epub 2008 Feb 19.
2
Inhibition of nucleic acid biosynthesis makes little difference to formation of amphotericin B-tolerant persisters in Candida albicans biofilm.
Antimicrob Agents Chemother. 2015 Mar;59(3):1627-33. doi: 10.1128/AAC.03765-14. Epub 2014 Dec 29.
3
Candida albicans Amphotericin B-Tolerant Persister Formation is Closely Related to Surface Adhesion.
Mycopathologia. 2016 Feb;181(1-2):41-9. doi: 10.1007/s11046-015-9894-1. Epub 2015 Sep 18.
4
Apoptosis in Candida biofilms exposed to amphotericin B.
J Med Microbiol. 2010 Feb;59(Pt 2):149-157. doi: 10.1099/jmm.0.015784-0. Epub 2009 Nov 5.
5
Effect of amphotericin B alone or in combination with rifampicin or clarithromycin against Candida species biofilms.
Int J Artif Organs. 2011 Sep;34(9):766-70. doi: 10.5301/ijao.5000023.
6
Candida albicans biofilms produce antifungal-tolerant persister cells.
Antimicrob Agents Chemother. 2006 Nov;50(11):3839-46. doi: 10.1128/AAC.00684-06. Epub 2006 Aug 21.
7
Relevance of antifungal penetration in biofilm-associated resistance of Candida albicans and non-albicans Candida species.
J Med Microbiol. 2018 Jul;67(7):922-926. doi: 10.1099/jmm.0.000757. Epub 2018 May 16.
8
Dynamics of Mixed- Candida Species Biofilms in Response to Antifungals.
J Dent Res. 2018 Jan;97(1):91-98. doi: 10.1177/0022034517729351. Epub 2017 Aug 29.
9
In vitro method to study antifungal perfusion in Candida biofilms.
J Clin Microbiol. 2005 Feb;43(2):818-25. doi: 10.1128/JCM.43.2.818-825.2005.
10
[Biofilm production and antifungal susceptibility patterns of Candida species].
Mikrobiyol Bul. 2004 Jan-Apr;38(1-2):91-8.
引用本文的文献
1
Antifungal persistence: Clinical relevance and mechanisms.
PLoS Pathog. 2025 Sep 11;21(9):e1013456. doi: 10.1371/journal.ppat.1013456. eCollection 2025 Sep.
2
The impact of phenotypic heterogeneity on fungal pathogenicity and drug resistance.
FEMS Microbiol Rev. 2025 Jan 14;49. doi: 10.1093/femsre/fuaf001.
3
A prospective observational study on species differentiation and antifungal susceptibility pattern in patients with genital candidiasis.
Indian J Sex Transm Dis AIDS. 2024 Jan-Jun;45(1):11-14. doi: 10.4103/ijstd.ijstd_58_23. Epub 2024 Jun 6.
4
Synergistic activity of gold nanoparticles with amphotericin B on persister cells of Candida tropicalis biofilms.
J Nanobiotechnology. 2024 May 16;22(1):254. doi: 10.1186/s12951-024-02415-6.
5
Synergistic Effect of Plant Compounds in Combination with Conventional Antimicrobials against Biofilm of , and spp.
Pharmaceuticals (Basel). 2023 Oct 30;16(11):1531. doi: 10.3390/ph16111531.
6
New Attempts to Inhibit Methicillin-Resistant Biofilm? A Combination of Daptomycin and Azithromycin.
Infect Drug Resist. 2023 Nov 6;16:7029-7040. doi: 10.2147/IDR.S433439. eCollection 2023.
7
Macrophage internalization creates a multidrug-tolerant fungal persister reservoir and facilitates the emergence of drug resistance.
Nat Commun. 2023 Mar 2;14(1):1183. doi: 10.1038/s41467-023-36882-6.
8
Mixed Fungal Biofilms: From Mycobiota to Devices, a New Challenge on Clinical Practice.
Microorganisms. 2022 Aug 26;10(9):1721. doi: 10.3390/microorganisms10091721.
9
Studying Bacterial Persistence: Established Methods and Current Advances.
Methods Mol Biol. 2021;2357:3-20. doi: 10.1007/978-1-0716-1621-5_1.
10
: Pathogenicity and Resistance Mechanisms for Adaptation and Survival.
J Fungi (Basel). 2021 Aug 17;7(8):667. doi: 10.3390/jof7080667.
本文引用的文献
1
Role for cell density in antifungal drug resistance in Candida albicans biofilms.
Antimicrob Agents Chemother. 2007 Jul;51(7):2454-63. doi: 10.1128/AAC.01237-06. Epub 2007 May 14.
2
Persister cells, dormancy and infectious disease.
Nat Rev Microbiol. 2007 Jan;5(1):48-56. doi: 10.1038/nrmicro1557. Epub 2006 Dec 4.
3
Putative role of beta-1,3 glucans in Candida albicans biofilm resistance.
Antimicrob Agents Chemother. 2007 Feb;51(2):510-20. doi: 10.1128/AAC.01056-06. Epub 2006 Nov 27.
4
A small subpopulation of blastospores in candida albicans biofilms exhibit resistance to amphotericin B associated with differential regulation of ergosterol and beta-1,6-glucan pathway genes.
Antimicrob Agents Chemother. 2006 Nov;50(11):3708-16. doi: 10.1128/AAC.00997-06. Epub 2006 Sep 11.
5
Candida albicans biofilms produce antifungal-tolerant persister cells.
Antimicrob Agents Chemother. 2006 Nov;50(11):3839-46. doi: 10.1128/AAC.00684-06. Epub 2006 Aug 21.
6
Biofilm matrix of Candida albicans and Candida tropicalis: chemical composition and role in drug resistance.
J Med Microbiol. 2006 Aug;55(Pt 8):999-1008. doi: 10.1099/jmm.0.46569-0.
7
Candida biofilms: an update.
Eukaryot Cell. 2005 Apr;4(4):633-8. doi: 10.1128/EC.4.4.633-638.2005.
8
Candida biofilm resistance.
Drug Resist Updat. 2004 Aug-Oct;7(4-5):301-9. doi: 10.1016/j.drup.2004.09.002.
9
Penetration of Candida biofilms by antifungal agents.
Antimicrob Agents Chemother. 2004 Sep;48(9):3291-7. doi: 10.1128/AAC.48.9.3291-3297.2004.
10
Candida infections of medical devices.
Clin Microbiol Rev. 2004 Apr;17(2):255-67. doi: 10.1128/CMR.17.2.255-267.2004.
Zotero 插件