Kojic Erna M, Darouiche Rabih O
Medical Service, Infectious Disease Section, Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Clin Microbiol Rev. 2004 Apr;17(2):255-67. doi: 10.1128/CMR.17.2.255-267.2004.
The number of indwelling medical devices is escalating, and an increasing proportion of device-related infections are being caused by Candida spp. Candida spp. produce biofilms on synthetic materials, which facilitates adhesion of the organisms to devices and renders them relatively refractory to medical therapy. Management of device-related Candida infections can be challenging. Removal of the infected device is generally needed to establish cure of Candida infections of medical devices. However, since the pathogenesis of Candida bloodstream infection is complicated, more studies are necessary to determine the role of catheter exchange in patients with both gastrointestinal tract mucositis and indwelling catheters. The medical and economic impact of these infections is enormous.
植入式医疗设备的数量正在不断增加，由念珠菌属引起的与设备相关的感染比例也在上升。念珠菌属在合成材料上形成生物膜，这有助于微生物附着在设备上，并使它们对医学治疗相对具有抗性。与设备相关的念珠菌感染的管理可能具有挑战性。通常需要移除受感染的设备以治愈医疗器械的念珠菌感染。然而，由于念珠菌血流感染的发病机制复杂，需要更多的研究来确定在患有胃肠道粘膜炎和留置导管的患者中更换导管的作用。这些感染对医学和经济的影响是巨大的。
