Brink N S, Murray A B
Department of Medical Microbiology, University of Cape Town.
S Afr Med J. 1991 Jun 1;79(11):653-4.
A prospective study of a low-dose (one-tenth) intradermal regimen using recombinant hepatitis B vaccine was undertaken during two consecutive years in 4th-year medical students. Eighty-one per cent of the vaccinees (123/152) sero-converted with anti-HBs levels of greater than 10 IU/l. The lower titre of hepatitis B surface antibodies compared with published studies on intramuscular immunisation, together with a sero-conversion rate of only 81%, makes the intradermal method, in our opinion, a suboptimal form of hepatitis B immunisation.
在连续两年的时间里，对四年级医学生采用低剂量（十分之一）重组乙肝疫苗皮内接种方案进行了一项前瞻性研究。81%的接种者（123/152）抗-HBs水平大于10 IU/l，实现了血清转化。与已发表的关于肌肉注射免疫的研究相比，乙肝表面抗体滴度较低，且血清转化率仅为81%，因此我们认为皮内接种方法是一种次优的乙肝免疫方式。
