Wedlich-Soldner Roland, Li Rong
Max-Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.
Semin Cell Dev Biol. 2008 Jun;19(3):224-33. doi: 10.1016/j.semcdb.2008.01.003. Epub 2008 Jan 20.
Cellular morphogenesis is a complex process and molecular studies in the last few decades have amassed a large amount of information that is difficult to grasp in any completeness. Fungal systems, in particular the budding and fission yeasts, have been important players in unravelling the basic structural and regulatory elements involved in a wide array of cellular processes. In this article, we address the design principles underlying the various processes of yeast and fungal morphogenesis. We attempt to explain the apparent molecular complexity from the perspective of the evolutionary theory of "facilitated variation". Following a summary of some of the most studied morphogenetic phenomena, we discuss, using recent examples, the underlying core processes and their associated "weak" regulatory linkages that bring about variation in morphogenetic phenotypes.
细胞形态发生是一个复杂的过程，过去几十年的分子研究积累了大量信息，要全面掌握这些信息并非易事。真菌系统，特别是出芽酵母和裂殖酵母，在揭示广泛细胞过程中涉及的基本结构和调控元件方面发挥了重要作用。在本文中，我们探讨酵母和真菌形态发生各种过程背后的设计原则。我们试图从“适应性变异”进化理论的角度来解释这种明显的分子复杂性。在总结了一些研究最多的形态发生现象之后，我们以最近的例子讨论了潜在的核心过程及其相关的“弱”调控联系，这些联系导致了形态发生表型的变异。
