Beger H G, Rau B M, Gansauge F, Poch B
Department of General and Visceral Surgery, University of Ulm (-9/2001), Ulm, Germany.
J Gastrointest Surg. 2008 Jun;12(6):1127-32. doi: 10.1007/s11605-008-0472-4. Epub 2008 Feb 26.
For treatment of inflammatory and benign neoplastic lesions of the pancreatic head, a subtotal or total pancreatic head resection is a limited surgical procedure with the impact of replacing the application of a Whipple procedure. The objective of this work is to describe the technical modifications of subtotal and total pancreatic head resection for inflammatory and neoplastic lesions of the pancreas. The advantages of this limited surgical procedure are the preservation of the stomach, the duodenum and the extrahepatic biliary ducts for treatment of benign lesions of the pancreatic head, papilla, and intrapancreatic segment of the common bile duct. For chronic pancreatitis with an inflammatory mass complicated by compression of the common bile duct or causing multiple pancreatic main duct stenoses and dilatations, a subtotal pancreatic head resection results in a long-lasting pain control. Performing, in addition, a biliary anastomosis or a Partington Rochelle type of pancreatic main duct drainage, respectively, is a logic and simple extension of the procedure. The rationale for the application of duodenum-preserving total pancreatic head resection for cystic neoplastic lesions are complete exstirpation of the tumor and, as a consequence, interruption of carcinogenesis of the neoplasia preventing development of pancreatic cancer. Duodenum-preserving total head resection necessitates additional biliary and duodenal anastomoses. For mono-centric IPMN, MCN, and SCA tumors, located in the pancreatic head, total duodenum-preserving pancreatic head resection can be performed without hospital mortality and resurgery for recurrency. Based on controlled clinical trials, duodenum-preserving pancreatic head resection is superior to the Whipple-type resection with regard to lower postoperative morbidity, almost no delay of gastric emptying, preservation of the endocrine function, lower frequency of rehospitalization, early professional rehabilitation, and establishment of a predisease level of quality of life.
The limited surgical procedures of subtotal or total pancreatic head resection are simple, safe, ensures free tumour margins and replace in the authors institution the application of a Whipple-type head resection.
对于胰头部炎性和良性肿瘤性病变的治疗,胰头次全切除或全切除是一种有限的外科手术,对替代胰十二指肠切除术的应用产生了影响。本研究的目的是描述针对胰腺炎性和肿瘤性病变的胰头次全切除和全切除的技术改良。这种有限的外科手术的优点在于,对于胰头部、乳头及胆总管胰腺内段的良性病变,可保留胃、十二指肠和肝外胆管。对于伴有炎性肿块且并发胆总管受压或导致多条胰腺主胰管狭窄和扩张的慢性胰腺炎,胰头次全切除可实现长期的疼痛控制。此外,分别进行胆管吻合或Partington Rochelle型主胰管引流是该手术合理且简单的扩展。对于囊性肿瘤性病变应用保留十二指肠的胰头全切除术的理论依据是肿瘤的完全切除,从而阻断肿瘤的致癌过程,预防胰腺癌的发生。保留十二指肠的胰头全切除需要额外进行胆管和十二指肠吻合。对于位于胰头部的单中心导管内乳头状黏液瘤(IPMN)、黏液性囊性肿瘤(MCN)和浆液性囊性腺瘤(SCA)肿瘤,可进行保留十二指肠的胰头全切除,且无医院死亡病例,也无需因复发而再次手术。基于对照临床试验,保留十二指肠的胰头切除术在术后发病率较低、几乎无胃排空延迟、保留内分泌功能、再住院频率较低、早期职业康复以及建立疾病前生活质量水平方面优于胰十二指肠切除术式。
胰头次全切除或全切除这种有限的外科手术操作简单、安全,能确保切缘无肿瘤残留,并在作者所在机构替代了胰十二指肠切除术式的应用。