多瘤病毒感染的小鼠肾细胞中的DNA聚合酶
DNA polymerases in polyoma virus-infected mouse kidney cells.
作者信息
Wintersberger U, Wintersberger E
出版信息
J Virol. 1975 Nov;16(5):1095-100. doi: 10.1128/JVI.16.5.1095-1100.1975.
Abstract
Infection of arrested mouse kidney cells by polyoma virus results in the induction of the cellular 6-8S DNA polymerase activity. Levels of this enzyme increase two- to threefold in the cytoplasm but seven- to tenfold in nuclei and nuclear extract, suggesting an accumulation of the enzyme in the nucleus. Experiments using the inhibitor of DNA synthesis, fluordeoxyuridine, indicate that this accumulation is linked to active DNA synthesis. The activity and cellular distribution of the small 3.4S DNA polymerase remains unchanged.
摘要
多瘤病毒感染停滞状态的小鼠肾细胞会诱导细胞6 - 8S DNA聚合酶活性。这种酶在细胞质中的水平增加两到三倍，但在细胞核和核提取物中增加七到十倍，表明该酶在细胞核中积累。使用DNA合成抑制剂氟脱氧尿苷的实验表明，这种积累与活跃的DNA合成有关。小的3.4S DNA聚合酶的活性和细胞分布保持不变。
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