Wu Xiaodong, Tanwar Pradeep Singh, Raftery Laurel A
Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA.
Semin Cell Dev Biol. 2008 Jun;19(3):271-82. doi: 10.1016/j.semcdb.2008.01.004. Epub 2008 Jan 20.
Epithelial morphogenesis is important for organogenesis and pivotal for carcinogenesis, but mechanisms that control it are poorly understood. The Drosophila follicular epithelium is a genetically tractable model to understand these mechanisms in vivo. This epithelium of follicle cells encases germline cells to create an egg. In this review, we summarize progress toward understanding mechanisms that maintain the epithelium or permit migrations essential for oogenesis. Cell-cell communication is important, but the same signals are used repeatedly to control distinct events. Understanding intrinsic mechanisms that alter responses to developmental signals will be important to understand regulation of cell shape and organization.
上皮形态发生对器官形成很重要，对癌症发生也至关重要，但控制它的机制却知之甚少。果蝇卵泡上皮是在体内理解这些机制的一个易于进行遗传学研究的模型。这种卵泡细胞上皮包裹生殖细胞以形成卵子。在本综述中，我们总结了在理解维持上皮或允许卵子发生所必需的迁移的机制方面取得的进展。细胞间通讯很重要，但相同的信号会反复用于控制不同的事件。理解改变对发育信号反应的内在机制对于理解细胞形状和组织的调控将很重要。
