Auroux M R, Jacques L, Mathieu D, Auer J
Biologie de la Reproduction et du Développement, CHU Bicêtre, Le Kremlin Bicetre, France.
Int J Androl. 1991 Aug;14(4):264-70. doi: 10.1111/j.1365-2605.1991.tb01091.x.
The effects of urogenital infection on male fertility are controversial. The object of this study was to assess whether contact between E. coli, one of the bacteria encountered most frequently in semen cultures, and sperm was involved in decreasing motility of the sperm. Sperm from healthy donors were therefore incubated at two concentrations (1.10(7) and 4.10(7) ml-1) with bacteria (10(4) and 10(6) bacteria ml-1 respectively). Sperm motility was assessed as a function of time. The endotoxin effect was also evaluated. Aliquots of the sperm were used as controls. The motility of a population of 10(6) sperm ml-1 was reduced significantly more by the presence of 10(6) ml-1 E. coli than a sperm population four times more numerous. Since the endotoxin had no effect on sperm motility, it is possible this phenomenon is due to bacterial adherence to the sperm. From this study, it is therefore probable that the presence of E. coli in semen decreases sperm motility, but that this depends on the sperm:bacterial ratio ml semen-1.
泌尿生殖系统感染对男性生育能力的影响存在争议。本研究的目的是评估精液培养中最常遇到的细菌之一大肠杆菌与精子之间的接触是否会导致精子活力下降。因此，将来自健康供体的精子以两种浓度（1×10⁷和4×10⁷个/毫升）与细菌（分别为10⁴和10⁶个/毫升）一起孵育。根据时间评估精子活力。还评估了内毒素的作用。将精子等分试样用作对照。每毫升含10⁶个大肠杆菌的情况下，每毫升10⁶个精子群体的活力下降幅度明显大于数量为其四倍的精子群体。由于内毒素对精子活力没有影响，因此这种现象可能是由于细菌附着在精子上。因此，从这项研究来看，精液中大肠杆菌的存在可能会降低精子活力，但这取决于每毫升精液中的精子与细菌比例。
