Department of Otolaryngology Head and Neck Surgery, the Fourth Hospital of Hebei Medical University and Hebei Tumor Hospital, Shijiazhuang, China,
Department of Otolaryngology Head and Neck Surgery, the Fourth Hospital of Hebei Medical University and Hebei Tumor Hospital, Shijiazhuang, China.
Oncol Res Treat. 2022;45(6):353-365. doi: 10.1159/000524489. Epub 2022 Apr 11.
The objective of this study was to investigate the clinical characteristics, diagnosis, and treatment of inflammatory myofibroblastoma tumor (IMT) in the thyroid gland.
A total of 17 patients with IMT by pathology from 2010 to 2020 were included in this study. Clinical features, imaging features, treatment, and prognosis were analyzed in this retrospective study.
The case series comprised 5 males and 12 females, with an average age of 49.6 ± 15.36 years. The patients were divided into two cohorts: with IMT without further pathological changes and with further pathological changes of the thyroid gland (e.g., nodular goiter or autoimmune thyroid disease). No significant differences were detected in tumor size and extrathyroid extension between the two groups. Fine needle aspiration biopsy examination before the operation was performed in 2 cases, and rapid freezing pathology examination during the operation was performed in 7 cases. Ultrasound images of 5 cases with only one type of pathology, IMT, presented a high and intermediate risk of malignancy. In the other 11 cases with further pathological changes of the thyroid gland, the image could be very low risk of malignancy or benign feature. Only 2 cases showed a high risk of malignancy ultrasound features. 5/17 patients underwent preventive cervical lymph node dissection additional to thyroid surgery. None of the lymph nodes were confirmed positive by postoperative pathology. Thyroid ultrasound, computed tomography scan of the lungs, abdomen ultrasound, and thyroid function tests were routine follow-up tests. During the follow-up period of 26-141 months, 2 cases were lost, and remaining 15 cases had no recurrence or metastasis and were considered cured.
IMT in the thyroid gland is a rare disease with a good prognosis and surgical resection is the preferred treatment.
本研究旨在探讨甲状腺炎性肌纤维母细胞瘤（IMT）的临床特征、诊断和治疗。
本研究回顾性分析了 2010 年至 2020 年期间经病理证实的 17 例 IMT 患者的临床特征、影像学特征、治疗和预后。
该病例系列包括 5 例男性和 12 例女性，平均年龄为 49.6±15.36 岁。患者分为两组：一组为 IMT 无进一步甲状腺病变，另一组为甲状腺进一步病变（如结节性甲状腺肿或自身免疫性甲状腺疾病）。两组间肿瘤大小和甲状腺外侵犯无显著差异。术前有 2 例行细针抽吸活检检查，术中快速冰冻病理检查 7 例。5 例仅有一种病理类型 IMT 的超声图像表现为中高危恶性风险。在其他 11 例有进一步甲状腺病变的病例中，图像可能为低危恶性风险或良性特征。仅 2 例显示出高危恶性超声特征。17 例患者中有 5 例行甲状腺手术加预防性颈淋巴结清扫术。术后病理均未证实淋巴结阳性。甲状腺超声、肺部 CT 扫描、腹部超声和甲状腺功能检查是常规随访检查。在 26-141 个月的随访期间，2 例失访，其余 15 例无复发或转移，被认为治愈。
甲状腺 IMT 是一种罕见疾病，预后良好，手术切除是首选治疗方法。
