Turner R F, Harrison D J, Rajotte R V
Surgical-Medical Research Institute, University of Alberta, Edmonton, Canada.
Biomaterials. 1991 May;12(4):361-8. doi: 10.1016/0142-9612(91)90003-s.
The first biocompatibility studies on the DuPont perfluorosulphonic acid polymer (Nafion) are presented. Presterilized samples of commercially cast and solution cast Nafion membranes were implanted subcutaneously, intraperitoneally and intravenously in male Sprague-Dawley rats. Scanning electron microscopy and histological examination of explanted samples and surrounding tissues reveal little, if any, evidence of acute or chronic foreign body inflammatory response. The fibrous capsules surrounding the implant remain nominally thin (less than 100 microns) after more than 3 months in situ, while the surrounding tissue remains well vascularized. Nafion polymer exhibits sufficient biocompatibility to make it a viable candidate for some implantable biosensor applications. It may, however, be necessary to compensate for the effect of the progression of fibrous encapsulation on sensor performance, particularly during the acute response stage.
首次展示了对杜邦全氟磺酸聚合物（Nafion）的生物相容性研究。将商业浇铸和溶液浇铸的Nafion膜的预灭菌样品皮下、腹腔内和静脉内植入雄性Sprague-Dawley大鼠体内。对取出的样品和周围组织进行扫描电子显微镜检查和组织学检查发现，几乎没有（如果有的话）急性或慢性异物炎症反应的证据。植入物周围的纤维囊在原位放置3个多月后仍保持名义上的薄度（小于100微米），而周围组织仍保持良好的血管化。Nafion聚合物表现出足够的生物相容性，使其成为一些可植入生物传感器应用的可行候选材料。然而，可能有必要补偿纤维包裹进展对传感器性能的影响，特别是在急性反应阶段。
