Klatsky Arthur L, Koplik Sheri, Kipp Harald, Friedman Gary D
Division of Cardiology, Department of Medicine, Kaiser Permanente Medical Care Program, Oakland, California, USA.
Am J Cardiol. 2008 Mar 15;101(6):825-7. doi: 10.1016/j.amjcard.2007.11.022. Epub 2008 Jan 18.
After decades of conflicting studies, the relation of coffee drinking to coronary artery disease (CAD) risk remains unresolved. Using Cox proportional-hazards models with 5 covariates, 127,212 subjects who supplied baseline data at voluntary health examinations from 1978 to 1985 were studied. Subsequently, 8,357 subjects were hospitalized for CAD. Coffee drinking was unrelated to CAD risk in 58,888 never smokers, but in ex-smokers and current baseline smokers, daily coffee intake was associated with higher CAD risk. This disparity was generally consistent in stratified subgroups. In conclusion, this relation of coffee consumption to increased CAD risk only in smokers could be explained by incomplete control for smoking, by other traits of smokers, or by an adverse biologic interaction of a coffee ingredient with smoking effect on CAD.
经过数十年相互矛盾的研究，喝咖啡与冠心病（CAD）风险之间的关系仍未得到解决。使用具有5个协变量的Cox比例风险模型，对1978年至1985年自愿健康检查时提供基线数据的127,212名受试者进行了研究。随后，8357名受试者因CAD住院。在58,888名从不吸烟者中，喝咖啡与CAD风险无关，但在前吸烟者和当前基线吸烟者中，每日咖啡摄入量与较高的CAD风险相关。这种差异在分层亚组中总体上是一致的。总之，咖啡消费与仅在吸烟者中增加的CAD风险之间的这种关系，可以通过对吸烟的不完全控制、吸烟者的其他特征，或咖啡成分与吸烟对CAD的影响之间的不良生物学相互作用来解释。
