Ramsay C N, Ellis P M, Zealley H
Lothian Health Board, Royal Hospital for Sick Children, Edinburgh, UK.
Biomed Pharmacother. 1991;45(6):267-72. doi: 10.1016/0753-3322(91)90028-r.
A study of Down's syndrome in Lothian for the years 1978-1989 revealed a significantly higher than expected incidence of cases in 1987. The increased incidence was particularly significant among women aged 35 years or more. The increase could not be attributed to demographic changes on birth rates or to the age distribution of the women concerned. A temporal association between the cluster of cases and the events at Chernobyl in April 1986 was demonstrated. However, according to current understanding, there is no biologically plausible explanation to link the 2 events, given the reported levels of radioactive fallout in the Lothian region, resulting from the Chernobyl disaster. An explanation for the increased incidence of Down's syndrome in 1987 remains outstanding.
一项针对1978年至1989年洛锡安地区唐氏综合征的研究显示，1987年的病例发病率显著高于预期。发病率的上升在35岁及以上的女性中尤为显著。这种增加不能归因于出生率的人口结构变化或相关女性的年龄分布。已证实病例群与1986年4月切尔诺贝利事件之间存在时间关联。然而，根据目前的认识，鉴于切尔诺贝利灾难导致洛锡安地区报告的放射性沉降物水平，没有生物学上合理的解释将这两个事件联系起来。1987年唐氏综合征发病率上升的原因仍未找到。
