Sperling K, Pelz J, Wegner R D, Schulzke I, Struck E
Institut für Humangenetik, Heubnerweg, Berlin, Germany.
Biomed Pharmacother. 1991;45(6):255-62. doi: 10.1016/0753-3322(91)90026-p.
For Berlin (West) the rate of trisomy 21 among newborn and all prenatally diagnosed cases can be almost completely recorded, including the maternal age distribution. During the 9-year-period from 1980 and 1988 the average number of trisomy 21 per month was about 2, following a Poisson distribution. A significant increase (P less than 0.01) was observed in January 1987, exactly 9 months after the Chernobyl accident. In a supraregional study based on greater than 30,000 prenatal diagnoses performed in 1986, no significant effect could be observed. However, the highest rates of trisomy 21 were observed in the more heavily contaminated, southern part of Germany. The majority of these fetuses were conceived during the period of greatest radioactive exposure. The data are discussed with respect to the effect of low-dose radiation around the time of conception on the induction of non-disjunction in man.
对于西柏林地区，新生儿及所有产前诊断出的21三体综合征病例的发生率几乎能够完全记录下来，包括产妇年龄分布情况。在1980年至1988年的9年期间，每月21三体综合征的平均病例数约为2例，呈泊松分布。1987年1月，即在切尔诺贝利事故发生整整9个月后，观察到显著增加（P<0.01）。在一项基于1986年进行的超过30000例产前诊断的超区域研究中，未观察到显著影响。然而，21三体综合征发生率最高的情况出现在德国受污染更严重的南部地区。这些胎儿中的大多数是在放射性暴露最严重的时期受孕的。文中就受孕前后低剂量辐射对人类减数分裂不分离诱导的影响进行了讨论。
