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Decreased anterior cingulate volume in combat-related PTSD.与战斗相关的创伤后应激障碍患者前扣带回体积减小。
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喙前扣带回体积可预测创伤后应激障碍认知行为疗法的治疗反应。

Rostral anterior cingulate volume predicts treatment response to cognitive-behavioural therapy for posttraumatic stress disorder.

作者信息

Bryant Richard A, Felmingham Kim, Whitford Thomas J, Kemp Andrew, Hughes Gerard, Peduto Anthony, Williams Leanne M

机构信息

Brain Dynamics Centre, Westmead Hospital, Sydney, Australia.

出版信息

J Psychiatry Neurosci. 2008 Mar;33(2):142-6.

PMID:18330460
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2265310/
Abstract

OBJECTIVE

To index the extent to which treatment response in posttraumatic stress disorder (PTSD) is predicted by rostral anterior cingulate cortex (rACC) volume.

METHOD

We used structural magnetic resonance imaging in a 1.5 T scanner to examine subjects with PTSD (n = 13), traumatized control subjects (n = 13) and nontraumatized control subjects (n = 13). Subjects with PTSD then participated in 8 sessions of cognitive-behavioural therapy, after which we reassessed them for PTSD.

RESULTS

According to voxel-based morphometry, treatment responders had larger rACC volume than nonresponders. Further, symptom reduction was associated with larger rACC volume.

CONCLUSION

Consistent with evidence for the neural bases of extinction learning, PTSD patients with larger rACC volume may be better able to regulate fear during cognitive-behavioural therapy and thus achieve greater treatment gains.

摘要

目的

探究前额叶前扣带回皮质（rACC）体积对创伤后应激障碍（PTSD）治疗反应的预测程度。

方法

我们使用1.5T扫描仪进行结构磁共振成像，以检查PTSD患者（n = 13）、受过创伤的对照受试者（n = 13）和未受过创伤的对照受试者（n = 13）。PTSD患者随后参加了8次认知行为治疗，之后我们对他们的PTSD情况进行了重新评估。

结果

根据基于体素的形态测量法，治疗有反应者的rACC体积比无反应者大。此外，症状减轻与更大的rACC体积相关。

结论

与消退学习的神经基础证据一致，rACC体积较大的PTSD患者在认知行为治疗期间可能更有能力调节恐惧，从而获得更大的治疗效果。