Greabu Maria, Battino M, Mohora Maria, Totan Alexandra, Spinu T, Totan C, Didilescu Andreea, Duţa Carmen
Department of Biochemistry, Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Rom J Intern Med. 2007;45(2):209-13.
The oral cavity, a very complex and unique milieu due to its dual function, respiratory and digestive, is the only place in the body where the mineralized tissue is exposed to the external environment. In this environment there are complex interactions between various surfaces: host soft and hard tissues, food, air and microorganisms. Saliva is in the middle of this environment and tries to cope with an ever-changing milieu. It includes a large number of inorganic and organic compounds, which act as a "mirror of the body's health". In addition to its other functions, saliva could constitute the first line of defence against oxidative stress. The body contains a number of protective antioxidant mechanisms. Saliva is also rich in antioxidants. We review the current available data and from our laboratory concerning antioxidant capacity of saliva. Substantial data are available in literature on the role of reactive oxygen species and antioxidants in diseases, but few information is available on oral pathology. Due to its composition and functions, saliva could have a significant role in controlling and/or modulating oxidative damages in the oral cavity.
口腔因其呼吸和消化的双重功能而成为一个非常复杂且独特的环境，是人体中矿化组织暴露于外部环境的唯一部位。在这个环境中，各种表面之间存在复杂的相互作用：宿主的软硬组织、食物、空气和微生物。唾液处于这个环境的中心，试图应对不断变化的环境。它包含大量无机和有机化合物，这些化合物可作为“身体健康的镜子”。除了其他功能外，唾液可能构成抵御氧化应激的第一道防线。人体含有多种保护性抗氧化机制。唾液中也富含抗氧化剂。我们回顾了目前可得的以及来自我们实验室关于唾液抗氧化能力的数据。文献中有大量关于活性氧和抗氧化剂在疾病中的作用的数据，但关于口腔病理学的信息却很少。由于其组成和功能，唾液在控制和/或调节口腔中的氧化损伤方面可能发挥重要作用。
