Sehatpour Pejman, Molholm Sophie, Schwartz Theodore H, Mahoney Jeannette R, Mehta Ashesh D, Javitt Daniel C, Stanton Patric K, Foxe John J
Cognitive Neurophysiology Laboratory, Program in Cognitive Neuroscience and Schizophrenia, Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA.
Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4399-404. doi: 10.1073/pnas.0708418105. Epub 2008 Mar 11.
Visual object-recognition is thought to involve activation of a distributed network of cortical regions, nodes of which include the lateral prefrontal cortex, the so-called lateral occipital complex (LOC), and the hippocampal formation. It has been proposed that long-range oscillatory synchronization is a major mode of coordinating such a distributed network. Here, intracranial recordings were made from three humans as they performed a challenging visual object-recognition task that required them to identify barely recognizable fragmented line-drawings of common objects. Subdural electrodes were placed over the prefrontal cortex and LOC, and depth electrodes were placed within the hippocampal formation. Robust beta-band coherence was evident in all subjects during processing of recognizable fragmented images. Significantly lower coherence was evident during processing of unrecognizable scrambled versions of the same. The results indicate that transient beta-band oscillatory coupling between these three distributed cortical regions may reflect a mechanism for effective communication during visual object processing.
视觉物体识别被认为涉及一个分布式皮质区域网络的激活，该网络的节点包括外侧前额叶皮质、所谓的枕外侧复合体（LOC）和海马结构。有人提出，长程振荡同步是协调这样一个分布式网络的主要模式。在此，对三名人类受试者进行了颅内记录，他们执行了一项具有挑战性的视觉物体识别任务，该任务要求他们识别常见物体几乎难以辨认的碎片化线条图。硬膜下电极放置在前额叶皮质和LOC上方，深度电极放置在海马结构内。在处理可识别的碎片化图像期间，所有受试者中均出现了明显的β波段相干性。在处理相同图像的不可识别的 scrambled 版本期间，相干性明显更低。结果表明，这三个分布式皮质区域之间的瞬时β波段振荡耦合可能反映了视觉物体处理过程中有效通信的一种机制。
