Calafat Antonia M, Ye Xiaoyun, Wong Lee-Yang, Reidy John A, Needham Larry L
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA.
Environ Health Perspect. 2008 Mar;116(3):303-7. doi: 10.1289/ehp.10768.
Triclosan is a synthetic chemical with broad antimicrobial activity that has been used extensively in consumer products, including personal care products, textiles, and plastic kitchenware.
This study was designed to assess exposure to triclosan in a representative sample > or = 6 years of age of the U.S. general population from the 2003-2004 National Health and Nutrition Examination Survey (NHANES).
We analyzed 2,517 urine samples using automated solid-phase extraction coupled to isotope dilution-high-performance liquid chromatography-tandem mass spectrometry.
We detected concentrations of total (free plus conjugated) triclosan in 74.6% of samples at concentrations of 2.4-3,790 microg/L. The geometric mean and 95th percentile concentrations were 13.0 microg/L (12.7 microg/g creatinine) and 459.0 microg/L (363.8 mug/g creatinine), respectively. We observed a curvilinear relation between age and adjusted least square geometric mean (LSGM) concentrations of triclosan. LSGM concentrations of triclosan were higher in people in the high household income than in people in low (p < 0.01) and medium (p = 0.04) income categories.
In about three-quarters of urine samples analyzed as part of NHANES 2003-2004, we detected concentrations of triclosan. Concentrations differed by age and socioeconomic status but not by race/ethnicity and sex. Specifically, the concentrations of triclosan appeared to be highest during the third decade of life and among people with the highest household incomes.
三氯生是一种具有广泛抗菌活性的合成化学物质，已广泛应用于消费品中，包括个人护理产品、纺织品和塑料厨具。
本研究旨在通过2003 - 2004年美国国家健康与营养检查调查（NHANES），评估美国6岁及以上普通人群代表性样本中三氯生的暴露情况。
我们使用自动固相萃取结合同位素稀释 - 高效液相色谱 - 串联质谱法分析了2517份尿液样本。
我们在74.6%的样本中检测到总（游离加结合）三氯生浓度为2.4 - 3790微克/升。几何平均浓度和第95百分位数浓度分别为13.0微克/升（12.7微克/克肌酐）和459.0微克/升（363.8微克/克肌酐）。我们观察到年龄与三氯生调整后的最小二乘几何平均（LSGM）浓度之间存在曲线关系。高家庭收入人群的三氯生LSGM浓度高于低收入（p < 0.01）和中等收入（p = 0.04）人群。
在作为2003 - 2004年NHANES一部分分析的约四分之三尿液样本中，我们检测到了三氯生浓度。浓度因年龄和社会经济地位而异，但不因种族/民族和性别而异。具体而言，三氯生浓度似乎在生命的第三个十年以及家庭收入最高人群中最高。
