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Monoclonal antibody OPD4 is reactive with CD45RO, but differs from UCHL1 by the absence of monocyte reactivity.

作者信息

Poppema S, Lai R, Visser L

机构信息

Department of Laboratory Medicine, Cross Cancer Institute, Edmonton, Alberta, Canada.

出版信息

Am J Pathol. 1991 Oct;139(4):725-9.

PMID:1833980
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1886304/
Abstract

Monoclonal antibody OPD4 was described as a novel monoclonal antibody recognizing a helper/inducer T-cell subset in paraffin-tissue sections. The authors have analyzed this reagent with respect to its molecular weight, reactivity with leukocyte common antigen (LCA) transfectants and cell and tissue distribution. OPD4 was found to be reactive with the 180 kd molecular weight isoform of the leukocyte common antigen family, similar to antibody UCHL1 and therefore can be considered as a CD45RO reagent. The only difference in distribution was found to be the absence of OPD4 reactivity with peripheral blood monocytes. Since OPD4 recognizes the same antigen on T cells as UCHL1, both reagents do not need applied in the immunophenotyping of lymphomas.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b298/1886304/624423fc17f9/amjpathol00094-0031-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b298/1886304/6d1299b9407b/amjpathol00094-0030-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b298/1886304/624423fc17f9/amjpathol00094-0031-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b298/1886304/6d1299b9407b/amjpathol00094-0030-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b298/1886304/624423fc17f9/amjpathol00094-0031-a.jpg

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1
Monoclonal antibody OPD4 is reactive with CD45RO, but differs from UCHL1 by the absence of monocyte reactivity.
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本文引用的文献

1
Diagnosis of human lymphoma with monoclonal antileukocyte antibodies.用单克隆抗白细胞抗体诊断人类淋巴瘤。
N Engl J Med. 1983 Nov 24;309(21):1275-81. doi: 10.1056/NEJM198311243092102.
2
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.在噬菌体T4头部组装过程中结构蛋白的切割
Nature. 1970 Aug 15;227(5259):680-5. doi: 10.1038/227680a0.
3
Monoclonal antibodies (MT1, MT2, MB1, MB2, MB3) reactive with leukocyte subsets in paraffin-embedded tissue sections.与石蜡包埋组织切片中的白细胞亚群发生反应的单克隆抗体（MT1、MT2、MB1、MB2、MB3）
接受天然人干扰素α（爱夫吉夫）治疗的单纯疱疹病毒（HSV）相关口腔病变患者的免疫特征
Pathol Oncol Res. 1997;3(1):44-46. doi: 10.1007/BF02893352.
4
Immunophenotypic and genotypic characterisation of multiple myelomas with adverse prognosis characterised by immunohistological expression of the T cell related antigen CD45RO (UCHL-1).以T细胞相关抗原CD45RO（UCHL-1）免疫组织化学表达为特征的预后不良多发性骨髓瘤的免疫表型和基因分型
J Clin Pathol. 1998 Jun;51(6):432-7. doi: 10.1136/jcp.51.6.432.
5
Lymphocytes infiltrating primary cutaneous neoplasms selectively express the cutaneous lymphocyte-associated antigen (CLA).浸润原发性皮肤肿瘤的淋巴细胞选择性表达皮肤淋巴细胞相关抗原（CLA）。
Am J Pathol. 1993 May;142(5):1556-64.
6
T lymphocytes, CD68-positive cells and vascularisation in thyroid carcinomas.甲状腺癌中的T淋巴细胞、CD68阳性细胞与血管生成
J Cancer Res Clin Oncol. 1994;120(11):651-6. doi: 10.1007/BF01245376.
7
Human atherosclerosis. III. Immunocytochemical analysis of the cell composition of lesions of young adults.
Am J Pathol. 1992 Apr;140(4):907-14.
8
T lymphocytes expressing HECA-452 epitope are present in cutaneous acute graft-versus-host disease and erythema multiforme, but not in acute graft-versus-host disease in gut organs.表达HECA - 452表位的T淋巴细胞存在于皮肤急性移植物抗宿主病和多形红斑中，但不存在于肠道器官的急性移植物抗宿主病中。
Am J Pathol. 1992 Sep;141(3):691-8.
9
Infiltration of helper/inducer T lymphocytes heralds central nervous system damage in human T-cell leukemia virus infection.
Am J Pathol. 1992 May;140(5):1003-8.
Am J Pathol. 1987 Jun;127(3):418-29.
4
Characterization of CD45 and CD45R monoclonal antibodies using transfected mouse cell lines that express individual human leukocyte common antigens.使用表达个体人类白细胞共同抗原的转染小鼠细胞系对CD45和CD45R单克隆抗体进行表征。
J Immunol. 1988 Dec 1;141(11):3910-4.
5
Induction of suppression following autologous mixed lymphocyte reaction; role of a novel 2H4 antigen.自体混合淋巴细胞反应后抑制作用的诱导；一种新型2H4抗原的作用。
Eur J Immunol. 1987 Jan;17(1):97-103. doi: 10.1002/eji.1830170117.
6
A novel monoclonal antibody (OPD4) recognizing a helper/inducer T cell subset. Its application to paraffin-embedded tissues.一种识别辅助/诱导性T细胞亚群的新型单克隆抗体（OPD4）。其在石蜡包埋组织中的应用。
Am J Pathol. 1989 Jun;134(6):1339-46.
7
The monoclonal antibody, UCHL1, recognizes a 180,000 MW component of the human leucocyte-common antigen, CD45.单克隆抗体UCHL1可识别人类白细胞共同抗原CD45的一个分子量为180,000的组分。
Immunology. 1988 Jun;64(2):331-6.
8
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Immunology. 1986 May;58(1):63-70.
9
Tissue distribution of restricted leukocyte common antigens. A comprehensive study with protein- and carbohydrate-specific CD45R antibodies.
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10
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J Immunol. 1991 Jul 1;147(1):218-23.