Ishiyama Haruaki, Okubo Taro, Yasuda Tetsuro, Takahashi Yohei, Iguchi Kazuo, Kobayashi Jun'ichi
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
J Nat Prod. 2008 Apr;71(4):633-6. doi: 10.1021/np070684p. Epub 2008 Mar 18.
Four new briarane-type diterpenoids, brianodins A-D ( 1- 4), were isolated from a soft coral, Pachyclavularia sp., and the structures and relative stereochemistry of 1- 4 were elucidated on the basis of spectroscopic data. The absolute configurations of 3 and 4 were assigned by the MTPA method. Brianodin A ( 1) showed a modest cytotoxicity.
从软珊瑚厚指软珊瑚属（Pachyclavularia sp.）中分离出了四种新的蔷薇烷型二萜类化合物，即厚指软珊瑚素A - D（1 - 4），并根据光谱数据阐明了1 - 4的结构和相对立体化学。3和4的绝对构型通过MTPA方法确定。厚指软珊瑚素A（1）表现出一定的细胞毒性。
