来自软珊瑚厚指软珊瑚属的布赖诺丁A-D，一种刺囊烷型二萜类化合物

Brianodins A-D, briarane-type diterpenoids from soft coral Pachyclavularia sp.

作者信息

Ishiyama Haruaki, Okubo Taro, Yasuda Tetsuro, Takahashi Yohei, Iguchi Kazuo, Kobayashi Jun'ichi

机构信息

Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.

出版信息

J Nat Prod. 2008 Apr;71(4):633-6. doi: 10.1021/np070684p. Epub 2008 Mar 18.

DOI:10.1021/np070684p

PMID:18345642

Abstract

Four new briarane-type diterpenoids, brianodins A-D ( 1- 4), were isolated from a soft coral, Pachyclavularia sp., and the structures and relative stereochemistry of 1- 4 were elucidated on the basis of spectroscopic data. The absolute configurations of 3 and 4 were assigned by the MTPA method. Brianodin A ( 1) showed a modest cytotoxicity.

摘要

从软珊瑚厚指软珊瑚属（Pachyclavularia sp.）中分离出了四种新的蔷薇烷型二萜类化合物，即厚指软珊瑚素A - D（1 - 4），并根据光谱数据阐明了1 - 4的结构和相对立体化学。3和4的绝对构型通过MTPA方法确定。厚指软珊瑚素A（1）表现出一定的细胞毒性。