Major-Pedersen A, Ihlemann N, Hermann T S, Christiansen B, Dominguez H, Kveiborg B, Nielsen D B, Svendsen O L, Køber L, Torp-Pedersen C
Cardiology Research Clinic Y, Bispebjerg University Hospital, 2400 Copenhagen, NV, Denmark.
Exp Diabetes Res. 2008;2008:672021. doi: 10.1155/2008/672021.
BACKGROUND/AIMS: Postprandial hyperglycemia, an independent risk factor for cardiovascular disease, is accompanied by endothelial dysfunction. We studied the effect of oral glucose load on insulin and glucose fluctuations, and on postprandial endothelial function in healthy individuals in order to better understand and cope with the postprandial state in insulin resistant individuals.
We assessed post-oral glucose load endothelial function (flow mediated dilation), plasma insulin, and blood glucose in 9 healthy subjects.
The largest increases in delta FMD values (fasting FMD value subtracted from postprandial FMD value) occurred at 3 hours after both glucose or placebo load, respectively: 4.80 +/- 1.41 (P = .009) and 2.34 +/- 1.47 (P = .15). Glucose and insulin concentrations achieved maximum peaks at one hour post-glucose load.
Oral glucose load does not induce endothelial dysfunction in healthy individuals with mean insulin and glucose values of 5.6 mmol/L and 27.2 mmol/L, respectively, 2 hours after glucose load.
背景/目的：餐后高血糖是心血管疾病的独立危险因素，伴有内皮功能障碍。我们研究了口服葡萄糖负荷对健康个体胰岛素和血糖波动以及餐后内皮功能的影响，以便更好地理解和应对胰岛素抵抗个体的餐后状态。
我们评估了9名健康受试者口服葡萄糖负荷后的内皮功能（血流介导的血管舒张）、血浆胰岛素和血糖。
葡萄糖或安慰剂负荷后，FMD值变化量（餐后FMD值减去空腹FMD值）的最大增幅分别出现在3小时：4.80±1.41（P = 0.009）和2.34±1.47（P = 0.15）。葡萄糖负荷后1小时，葡萄糖和胰岛素浓度达到峰值。
在葡萄糖负荷后2小时，平均胰岛素和血糖值分别为5.6 mmol/L和27.2 mmol/L的健康个体中，口服葡萄糖负荷不会诱发内皮功能障碍。
