Reuter Juliane, Huyke Constance, Casetti Federica, Theek Carmen, Frank Uwe, Augustin Matthias, Schempp Christoph
Department of Dermatology, Competence Center Skintegral, University Medical Center Freiburg, Freiburg, Germany.
J Dtsch Dermatol Ges. 2008 Oct;6(10):847-51. doi: 10.1111/j.1610-0387.2008.06704.x. Epub 2008 Mar 26.
Coriander oil is used as an antimicrobial agent and as a natural fragrance. The present study investigated the anti-inflammatory potency of coriander oil in the ultraviolet (UV) erythema test in vivo.
40 volunteers were enrolled in this monocentric,randomized,placebo-controlled double-blind study.Test areas on the back were irradiated with the 1.5 fold minimal erythema dose UV-B. Subsequently, the test areas were treated under occlusion for 47 hours with a lipolotion containing 0.5% or 1.0% essential coriander oil. Hydrocortisone (1.0%) and betamethasone valerate (0.1%) in the vehicle served as positive controls.The vehicle was used as place-bo.The effect of the test substances on the UV-induced erythema was measured photometrically after 48 hours.Additionally,the skin tolerance of the test preparations was assessed on non-irradiated skin.
Compared to placebo, the lipolotion with 0.5% coriander oil significantly reduced the UV-induced erythema, but it was not as effective as hydrocortisone. The skin tolerance of both coriander oil concentrations was excellent.
The lipolotion containing coriander oil displayed a mild antiinflammatory effect in this study. It could be useful in the concomitant treatment of inflammatory skin diseases.
摘要 背景：芫荽油用作抗菌剂和天然香料。本研究在紫外线（UV）红斑体内试验中研究了芫荽油的抗炎效力。
40名志愿者参与了这项单中心、随机、安慰剂对照双盲研究。背部的试验区域用1.5倍最小红斑量的UV - B进行照射。随后，试验区域用含0.5%或1.0%芫荽精油的润肤乳封闭处理47小时。赋形剂中的氢化可的松（1.0%）和戊酸倍他米松（0.1%）用作阳性对照。赋形剂用作安慰剂。48小时后用光度法测量受试物质对紫外线诱导红斑的影响。此外，在未照射的皮肤上评估受试制剂的皮肤耐受性。
与安慰剂相比，含0.5%芫荽油的润肤乳显著减轻了紫外线诱导的红斑，但不如氢化可的松有效。两种芫荽油浓度的皮肤耐受性都很好。
在本研究中，含芫荽油的润肤乳显示出轻度抗炎作用。它可能有助于炎症性皮肤病的辅助治疗。
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