Kern Catherine, Gombert Christian, Roso Alicia, Garcia Christine
Seppic Research and Innovation, La Garenne Colombes, France.
Food Nutr Res. 2022 Mar 23;66. doi: 10.29219/fnr.v66.7730. eCollection 2022.
Sensitive skin is a common condition that affects many people in the world, especially women. This syndrome is defined by the occurrence of unpleasant sensations such as stinging and burning in response to stimuli that should not normally provoke such sensations. Coriander seed oil (CSO) is a 100% virgin oil of coriander seeds and boasts a specific composition of fatty acids, mainly petroselinic acid (60-75%). It has demonstrated its ability to regulate inflammation (NF-κB pathway) and nociception (TRPA1 pathway), two mechanisms supporting sensitive skin, in previous research. It was, therefore, a good candidate to be tested on sensitive skin conditions. A pilot clinical study was conducted to evaluate the effect of this ingredient on healthy women showing excessive skin reactions, mainly redness and discomfort when subjected to external stress. The results showed that the daily consumption of 200 mg of CSO for 28 days effectively reduced redness induced by stripping stress and itching induced by stinging stress. It also improved the perception of skin sensitivity and reactivity after 56 days of consumption. These clinical results confirmed that CSO is a promising ingredient to contribute to reducing reactivity in sensitive skin.
敏感性皮肤是一种常见病症，影响着世界上许多人，尤其是女性。这种综合征的定义是，皮肤在受到正常情况下不会引发此类感觉的刺激时，会出现刺痛和灼烧等不适感。芫荽籽油（CSO）是100%的芫荽籽初榨油，拥有特定的脂肪酸组成，主要是岩芹酸（60 - 75%）。在先前的研究中，它已证明能够调节炎症（NF-κB通路）和痛觉（TRPA1通路），这两种机制都与敏感性皮肤有关。因此，它是用于测试敏感性皮肤状况的理想候选物。开展了一项初步临床研究，以评估该成分对健康女性的影响，这些女性在受到外部压力时会出现过度的皮肤反应，主要是发红和不适。结果显示，连续28天每天服用200毫克CSO可有效减轻因剥脱性应激引起的发红以及因刺痛应激引起的瘙痒。在服用56天后，还改善了皮肤敏感性和反应性的感知。这些临床结果证实，CSO是一种有望帮助减轻敏感性皮肤反应性的成分。
