Colley Shane M, Iyer Kavitha R, Leedman Peter J
Laboratory for Cancer Medicine, Western Australian Institute for Medical Research and Centre for Medical Research, the University of Western Australia, WA, Australia.
IUBMB Life. 2008 Mar;60(3):159-64. doi: 10.1002/iub.22.
Nuclear receptor (NR) coregulators are key modulators of hormone signaling. Discovery of steroid receptor RNA activator (SRA), a coregulator that is active as a RNA, transformed thinking in the field of hormone action. The subsequent identification of SRA-binding coregulator proteins, including p68, SHARP and more recently SLIRP, has provided important insight into SRA's mechanism of action and potentially offers new opportunities to target NR signaling pathways for therapeutic gain. Here we outline advances in the field of NR coregulator biology, with a bias on recent progress in understanding SRA-protein interactions.
核受体（NR）共调节因子是激素信号传导的关键调节因子。类固醇受体RNA激活剂（SRA）作为一种RNA发挥作用的共调节因子的发现，改变了激素作用领域的观念。随后对SRA结合共调节因子蛋白的鉴定，包括p68、SHARP以及最近发现的SLIRP，为深入了解SRA的作用机制提供了重要线索，并有可能为靶向NR信号通路以获得治疗益处提供新的机会。在此，我们概述了NR共调节因子生物学领域的进展，重点介绍了在理解SRA-蛋白质相互作用方面的最新进展。
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