Tesauro Manfredi, Schinzari Francesca, Rovella Valentina, Melina Domenico, Mores Nadia, Barini Angela, Mettimano Marco, Lauro Davide, Iantorno Micaela, Quon Michael J, Cardillo Carmine
Università di Tor Vergata, Rome, Italy.
Diabetes Care. 2008 Jul;31(7):1439-41. doi: 10.2337/dc08-0219. Epub 2008 Apr 4.
Obesity is associated with chronic inflammation due to overproduction of proinflammatory cytokines, including tumor necrosis factor (TNF)-alpha. We assessed the effects of TNF-alpha neutralization by infliximab on vascular reactivity during hyperinsulinemia in obesity-related metabolic syndrome.
Vascular responses to intra-arterial infusion of acetylcholine (ACh) and sodium nitroprusside (SNP) were assessed in patients with metabolic syndrome, before and after administration of infliximab.
Patients had blunted vasodilator responses to ACh and SNP during hyperinsulinemia compared with control subjects; a potentiation of the responsiveness to both ACh and SNP, however, was observed in patients following infliximab. The antioxidant vitamin C improved the vasodilator response to ACh in patients with metabolic syndrome, but its effect was not further enhanced by concurrent administration of infliximab.
TNF-alpha neutralization ameliorates vascular reactivity in metabolic syndrome during hyperinsulinemia, likely in relation to decreased oxidative stress, thereby suggesting an involvement of inflammatory cytokines in vascular dysfunction of these patients.
肥胖与促炎细胞因子过度产生导致的慢性炎症相关，其中包括肿瘤坏死因子（TNF）-α。我们评估了英夫利昔单抗中和TNF-α对肥胖相关代谢综合征患者高胰岛素血症期间血管反应性的影响。
在代谢综合征患者中，于给予英夫利昔单抗之前和之后，评估动脉内输注乙酰胆碱（ACh）和硝普钠（SNP）时的血管反应。
与对照受试者相比，代谢综合征患者在高胰岛素血症期间对ACh和SNP的血管舒张反应减弱；然而，在接受英夫利昔单抗治疗后的患者中，观察到对ACh和SNP的反应性均增强。抗氧化剂维生素C改善了代谢综合征患者对ACh的血管舒张反应，但同时给予英夫利昔单抗并未进一步增强其效果。
中和TNF-α可改善代谢综合征患者在高胰岛素血症期间的血管反应性，这可能与氧化应激降低有关，从而提示炎症细胞因子参与了这些患者的血管功能障碍。
