美国分离出的人葡萄球菌临床分离株中cfr介导的对利奈唑胺耐药性的首次报告。
First report of cfr-mediated resistance to linezolid in human staphylococcal clinical isolates recovered in the United States.
作者信息
Mendes Rodrigo E, Deshpande Lalitagauri M, Castanheira Mariana, DiPersio Joseph, Saubolle Michael A, Jones Ronald N
机构信息
JMI Laboratories, North Liberty, IA 52317, USA.
出版信息
Antimicrob Agents Chemother. 2008 Jun;52(6):2244-6. doi: 10.1128/AAC.00231-08. Epub 2008 Apr 7.
Abstract
Linezolid resistance has dominantly been mediated by mutations in 23S rRNA or ribosomal protein L4 genes. Recently, cfr has demonstrated the ability to produce a phenotype of resistance to not only oxazolidinones, but also other antimicrobial classes (phenicols, lincosamides, pleuromutilins, and streptogramin A). We describe the first detection of cfr-mediated linezolid resistance in Staphylococcus aureus and Staphylococcus epidermidis recovered from human infection cases monitored during the 2007 LEADER Program.
摘要
利奈唑胺耐药性主要由23S rRNA或核糖体蛋白L4基因的突变介导。最近，cfr已被证明不仅能产生对恶唑烷酮类药物的耐药表型，还能产生对其他抗菌药物类别（氯霉素类、林可酰胺类、截短侧耳素类和链阳菌素A）的耐药表型。我们描述了在2007年LEADER项目监测的人类感染病例中分离出的金黄色葡萄球菌和表皮葡萄球菌中首次检测到由cfr介导的利奈唑胺耐药性。
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