Varma Raja, Aronow Wilbert S, Basis Yana, Singh Tarundit, Kalapatapu Kumar, Weiss Melvin B, Pucillo Anthony L, Monsen Craig E
Department of Medicine, Cardiology Division, New York Medical College, Valhalla, New York, USA.
Am J Cardiol. 2008 Apr 15;101(8):1103-4. doi: 10.1016/j.amjcard.2007.12.013. Epub 2008 Feb 7.
Coronary angiography was performed because of chest pain in 198 patients (146 women, 52 men; mean age 66 years) who had dual-energy x-ray absorptiometry scans of the spine and left hip because of suspected osteoporosis or osteopenia. Of the 198 patients, 53 (27%) had osteoporosis, 79 (40%) had osteopenia, and 66 (33%) had normal bone mineral density (BMD). Obstructive coronary artery disease with >50% narrowing of > or =1 major coronary artery was present in 40 of 53 patients (76%) with osteoporosis, in 54 of 79 patients (68%) with osteopenia, and in 31 of 66 patients (47%) with normal BMD (p <0.005 comparing osteoporosis with normal BMD, p <0.01 comparing osteopenia with normal BMD). In conclusion, in patients who undergo coronary angiography because of chest pain, patients with osteoporosis or osteopenia have a higher prevalence of obstructive coronary artery disease than those with normal BMD.
198例因胸痛接受冠状动脉造影的患者（146名女性，52名男性；平均年龄66岁）因疑似骨质疏松或骨质减少接受了脊柱和左髋部双能X线吸收测定扫描。在这198例患者中，53例（27%）患有骨质疏松，79例（40%）患有骨质减少，66例（33%）骨矿物质密度（BMD）正常。53例骨质疏松患者中有40例（76%）、79例骨质减少患者中有54例（68%）、66例BMD正常患者中有31例（47%）存在阻塞性冠状动脉疾病，即至少1条主要冠状动脉狭窄>50%（骨质疏松与BMD正常者相比，p<0.005；骨质减少与BMD正常者相比，p<0.01）。总之，在因胸痛接受冠状动脉造影的患者中，骨质疏松或骨质减少患者阻塞性冠状动脉疾病的患病率高于BMD正常者。
