Beer S, Saely C H, Hoefle G, Rein P, Vonbank A, Breuss J, Gaensbacher B, Muendlein A, Drexel H
Vorarlberg Institute for Vascular Investigation and Treatment, Feldkirch, Austria.
Osteoporos Int. 2010 Oct;21(10):1695-701. doi: 10.1007/s00198-009-1103-y. Epub 2009 Nov 21.
This study for the first time investigates the association of bone mineral density (BMD) with angiographically determined coronary atherosclerosis in men. Our data show that the prevalence of low BMD is very high in men undergoing coronary angiography. However, neither osteopenia nor osteoporosis is associated with an increased prevalence of angiographically determined coronary atherosclerosis.
The association of low BMD with angiographically determined coronary atherosclerosis in men is unknown.
We enrolled 623 consecutive men undergoing coronary angiography for the evaluation of established or suspected coronary artery disease (CAD). BMD was assessed by dual X-ray absorptiometry. CAD was diagnosed in the presence of any coronary artery lumen narrowing at angiography; coronary stenoses with lumen narrowing > or =50% were considered significant.
From the total study cohort (mean age of 64 +/- 11 years), 207 patients (33.2%) had osteopenia and 65 (10.4%) had osteoporosis; at angiography, CAD was diagnosed in 558 patients (89.6%) and 403 (64.7%) had significant coronary stenoses. In multivariate logistic regression analysis neither osteopenia nor osteoporosis was associated with an increased prevalence of CAD (adjusted odds ratios (ORs) = 0.71 [95% confidence interval 0.40-1.23]; p = 0.222 and 1.03 [0.38-2.80]; p = 0.955, respectively) or with significant coronary stenoses (OR 0.74 [0.52-1.07], p = 0.112 and 0.72 [0.41-1.26]; p = 0.251, respectively). Also, as a continuous variable, BMD was not associated with angiographically diagnosed CAD.
The prevalence of low BMD is very high in men undergoing coronary angiography. However, low BMD is not associated with angiographically determined coronary atherosclerosis in men.
本研究首次调查了男性骨密度（BMD）与血管造影确定的冠状动脉粥样硬化之间的关联。我们的数据显示，接受冠状动脉造影的男性中低骨密度的患病率非常高。然而，骨量减少和骨质疏松均与血管造影确定的冠状动脉粥样硬化患病率增加无关。
男性中低骨密度与血管造影确定的冠状动脉粥样硬化之间的关联尚不清楚。
我们纳入了623例连续接受冠状动脉造影以评估已确诊或疑似冠状动脉疾病（CAD）的男性。通过双能X线吸收法评估骨密度。血管造影时存在任何冠状动脉管腔狭窄则诊断为CAD；管腔狭窄≥50%的冠状动脉狭窄被视为严重狭窄。
在整个研究队列（平均年龄64±11岁）中，207例患者（33.2%）有骨量减少，65例（10.4%）有骨质疏松；血管造影时，558例患者（89.6%）诊断为CAD，403例（64.7%）有严重冠状动脉狭窄。在多因素逻辑回归分析中，骨量减少和骨质疏松均与CAD患病率增加无关（调整后的优势比（OR）分别为0.71[95%置信区间0.40 - 1.23]；p = 0.222和1.03[0.38 - 2.80]；p = 0.955），也与严重冠状动脉狭窄无关（OR分别为0.74[0.52 - 1.07]，p = 0.112和0.72[0.41 - 1.26]；p = 0.251）。此外，作为连续变量，骨密度与血管造影诊断的CAD无关。
接受冠状动脉造影的男性中低骨密度的患病率非常高。然而，男性中低骨密度与血管造影确定的冠状动脉粥样硬化无关。
