Department of Medical and Surgical Science, University Magna Grecia, Catanzaro, Italy.
Endocrine. 2013 Feb;43(1):59-64. doi: 10.1007/s12020-012-9813-x. Epub 2012 Oct 9.
Osteoporosis is a metabolic bone disorder affecting million of people worldwide. Increased understanding of bone disease has led to a greater recognition of factors affecting bones, and consequently many secondary causes of osteoporosis were demonstrated. In this study, we aim to explore possible causes of bone loss and fractures in subjects affected by chronic inflammatory disease and to suggest new targets for intervention. In fact several studies, evaluated to perform this study, suggest that the patients with chronic inflammatory disease could be at high risk for fractures due to bone loss as consequence of malnutrition, caused by inflammation and hormonal change. Consequently, some actions could derive from the considerations of these mechanisms: a change in actual approach of chronic patients, that may include the investigation on the possible presence of osteoporosis, as well as further research on this topic to find a better therapy to prevent osteoporosis considering all the mechanisms described.
骨质疏松症是一种影响全球数百万人的代谢性骨病。对骨骼疾病的认识不断提高，导致人们越来越认识到影响骨骼的因素，因此许多继发性骨质疏松症的病因已被证实。在这项研究中，我们旨在探讨慢性炎症性疾病患者骨丢失和骨折的可能原因，并为干预提供新的靶点。事实上，几项研究评估表明，由于炎症和激素变化导致的营养不良，慢性炎症性疾病患者可能有骨折的高风险。因此，从这些机制的考虑中可能会产生一些行动：改变对慢性患者的实际治疗方法，可能包括调查骨质疏松症的可能存在，以及进一步研究这一课题，以找到更好的治疗方法来预防骨质疏松症，考虑到所有描述的机制。
