Stabholz A, Shapira J, Shur D, Friedman M, Guberman R, Sela M N
Faculty of Dental Medicine, Hebrew University-Hadassah, Jerusalem.
Clin Prev Dent. 1991 Sep-Oct;13(5):9-14.
The effect of local applications of sustained-release delivery polymer containing chlorhexidine as an adjunct to mechanical plaque removal was studied in institutionalized children with Down's syndrome. Thirty children, ages 8-13, participated in the study. Clinical parameters (P1I, GI, papillary bleeding) were recorded and bacterial samples from selected permanent teeth were collected and processed before and following treatment. Following the registration of clinical findings and collection of plaque, all children had their teeth scaled and polished and were randomized into three treatment groups of ten subjects each: Subjects in group I had their teeth coated with ethyl cellulose containing chlorhexidine; those in group II had their teeth coated with placebo polymer and those in group III received no further treatment. Individual oral hygiene habits were not interfered with. The application of the solutions to the respective groups was done every 3 days for 21 days. Chlorhexidine treatment significantly reduced the PLI, GI total aerobic counts and S. viridans counts compared to no treatment. The placebo group showed similar effects to that of the chlorhexidine-treated group except for the total aerobic counts which were not affected. The results suggest that the use of chlorhexidine in a sustained-release dosage form applied to the tooth surfaces may prove useful in the control of plaque and its sequela in children with Down's syndrome.
在患有唐氏综合征的福利院儿童中，研究了含氯己定的缓释递送聚合物局部应用作为机械性去除牙菌斑辅助手段的效果。30名8至13岁的儿童参与了该研究。记录临床参数（菌斑指数、牙龈指数、龈乳头出血情况），并在治疗前后收集选定恒牙的细菌样本并进行处理。在记录临床结果和收集牙菌斑后，所有儿童均进行了洗牙和抛光，然后随机分为三个治疗组，每组10名受试者：第一组受试者的牙齿涂有含氯己定的乙基纤维素；第二组受试者的牙齿涂有安慰剂聚合物；第三组受试者不再接受进一步治疗。个人口腔卫生习惯未受干扰。每隔3天对各治疗组进行一次溶液涂抹，共进行21天。与未治疗相比，氯己定治疗显著降低了菌斑指数、牙龈指数、需氧菌总数和草绿色链球菌计数。安慰剂组除需氧菌总数未受影响外，显示出与氯己定治疗组相似的效果。结果表明，将氯己定以缓释剂型应用于牙齿表面可能有助于控制唐氏综合征儿童的牙菌斑及其后遗症。
