Friedman M, Harari D, Raz H, Golomb G, Brayer L
J Dent Res. 1985 Nov;64(11):1319-21. doi: 10.1177/00220345850640111401.
We studied the effectiveness of a sustained-release delivery system for chlorhexidine in plaque prevention. A clinical trial in a group of eight students wearing orthodontic appliances coated by ethyl cellulose polymer containing the drug demonstrated that plaque accumulation was decreased for a period of four days. All oral procedures had been withdrawn during the clinical study. No side-effects of chlorhexidine, such as tooth staining and unpleasant taste, were observed.
我们研究了洗必泰缓释给药系统在预防牙菌斑方面的有效性。一项针对八名佩戴含该药物的乙基纤维素聚合物涂层正畸矫治器的学生进行的临床试验表明，在四天时间里牙菌斑堆积有所减少。临床研究期间所有口腔操作均已停止。未观察到洗必泰的副作用，如牙齿染色和异味。
