Ghosh Anupam, Das Bidus Kanti, Roy Arup, Mandal Biplab, Chandra Goutam
Department of Zoology, Bankura Christian College, Bankura, West Bengal, 722101, India.
J Nat Med. 2008 Apr;62(2):259-62. doi: 10.1007/s11418-007-0216-x. Epub 2007 Dec 5.
Antibacterial activity of hot aqueous and methanolic extracts prepared from six plants (Terminallia chebula, Terminallia bellerica, Phyllanthus emblica, Punica granatum, Lawsonia alba and Mikania micrantha) used in traditional folk medicines of India were screened against five pathogenic bacteria (Staphylococcus aureus MTCC 2940, Bacillus subtilis MTCC 441, Escherichia coli MTCC 739, Proteus vulgaris MTCC 426 and Enterobacter aerogenes MTCC 111). The highest antibacterial potentiality was exhibited by the methanolic leaf extract of T. chebula, followed by the aqueous fruit extract of T. bellerica. The leaf extract of T. chebula can be considered to be as equally potent as the most effective antibiotics, such as ciprofloxacin, gentamycin, kanamycin, ofloxacin and cephalexin. A sensitivity test performed with commonly used sensitivity test disks resulted in the appearance of multiple drug resistance phenotypes of the bacteria tested. A comparison of data in the inhibition zones of pathogenic bacteria showed that gentamycin, ofloxacin, kanamycin and tobramycin were effective against all of the bacterial strains tested.
对印度传统民间药物中使用的六种植物（诃子、毛诃子、余甘子、石榴、白番红花和薇甘菊）制备的热水提取物和甲醇提取物针对五种病原菌（金黄色葡萄球菌MTCC 2940、枯草芽孢杆菌MTCC 441、大肠杆菌MTCC 739、普通变形杆菌MTCC 426和气生肠杆菌MTCC 111）进行了抗菌活性筛选。诃子的甲醇叶提取物表现出最高的抗菌潜力，其次是毛诃子的水果实提取物。诃子的叶提取物可被认为与最有效的抗生素如环丙沙星、庆大霉素、卡那霉素、氧氟沙星和头孢氨苄具有同等效力。用常用的药敏试验纸片进行的敏感性试验导致受试细菌出现多重耐药表型。病原菌抑菌圈数据的比较表明，庆大霉素、氧氟沙星、卡那霉素和妥布霉素对所有受试菌株均有效。
