银屑病斑块中的辅助性T细胞17以及白细胞介素-23与银屑病之间的其他遗传联系。
T-helper 17 cells in psoriatic plaques and additional genetic links between IL-23 and psoriasis.
作者信息
Blauvelt Andrew
机构信息
Department of Dermatology, Oregon Health and Science University, Portland, Oregon, USA.
出版信息
J Invest Dermatol. 2008 May;128(5):1064-7. doi: 10.1038/jid.2008.85.
Abstract
T-helper 17 (Th17) cells are a newly appreciated T-cell subset, distinct from both Th1 and Th2 cells, that have been implicated in the pathogenesis of psoriasis and other autoimmune inflammatory diseases (Figure 1) (Fitch et al., 2007; Kastelein et al., 2007). IL-23 stimulates survival and proliferation of Th17 cells and thus serves as a key master cytokine regulator for these diseases.
摘要
辅助性T细胞17（Th17）是一种新发现的T细胞亚群，与Th1和Th2细胞不同，它与银屑病和其他自身免疫性炎症性疾病的发病机制有关（图1）（菲奇等人，2007年；卡斯特林等人，2007年）。白细胞介素-23刺激Th17细胞的存活和增殖，因此是这些疾病的关键主要细胞因子调节因子。
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