Blauvelt Andrew
Department of Dermatology, Oregon Health and Science University, Portland, Oregon, USA.
J Invest Dermatol. 2008 May;128(5):1064-7. doi: 10.1038/jid.2008.85.
T-helper 17 (Th17) cells are a newly appreciated T-cell subset, distinct from both Th1 and Th2 cells, that have been implicated in the pathogenesis of psoriasis and other autoimmune inflammatory diseases (Figure 1) (Fitch et al., 2007; Kastelein et al., 2007). IL-23 stimulates survival and proliferation of Th17 cells and thus serves as a key master cytokine regulator for these diseases.
辅助性T细胞17(Th17)是一种新发现的T细胞亚群,与Th1和Th2细胞不同,它与银屑病和其他自身免疫性炎症性疾病的发病机制有关(图1)(菲奇等人,2007年;卡斯特林等人,2007年)。白细胞介素-23刺激Th17细胞的存活和增殖,因此是这些疾病的关键主要细胞因子调节因子。