Carson John H, Gao Yuanzheng, Tatavarty Vedakumar, Levin Mikhail K, Korza George, Francone Victor P, Kosturko Linda D, Maggipinto Michael J, Barbarese Elisa
Department of Molecular Microbial and Structural Biology, University of Connecticut Health Center, Farmington, CT 06030, USA.
Biochim Biophys Acta. 2008 Aug;1779(8):453-8. doi: 10.1016/j.bbagrm.2008.04.002. Epub 2008 Apr 10.
In oligodendrocytes and neurons genetic information is transmitted from the nucleus to dendrites in the form of RNA granules. Here we describe how transport of multiple different RNA molecules in individual granules is analogous to the process of multiplexing in telecommunications. In both cases multiple messages are combined into a composite signal for transmission on a single carrier. Multiplexing provides a mechanism to coordinate local expression of ensembles of genes in myelin in oligodendrocytes and at synapses in neurons.
在少突胶质细胞和神经元中，遗传信息以RNA颗粒的形式从细胞核传递到树突。在此，我们描述了单个颗粒中多种不同RNA分子的运输如何类似于电信中的多路复用过程。在这两种情况下，多个信息都被组合成一个复合信号，以便在单个载体上传输。多路复用提供了一种机制，可协调少突胶质细胞中髓鞘以及神经元突触处基因集合的局部表达。
