通过成像技术揭示 RNA 生物学。
Illuminating RNA biology through imaging.
机构信息
Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Stem Cell Program, University of California San Diego, La Jolla, CA, USA.
出版信息
Nat Cell Biol. 2022 Jun;24(6):815-824. doi: 10.1038/s41556-022-00933-9. Epub 2022 Jun 13.
Abstract
RNA processing plays a central role in accurately transmitting genetic information into functional RNA and protein regulators. To fully appreciate the RNA life-cycle, tools to observe RNA with high spatial and temporal resolution are critical. Here we review recent advances in RNA imaging and highlight how they will propel the field of RNA biology. We discuss current trends in RNA imaging and their potential to elucidate unanswered questions in RNA biology.
摘要
RNA 处理在准确地将遗传信息传递给功能性 RNA 和蛋白质调节剂方面发挥着核心作用。为了全面了解 RNA 的生命周期，需要有能够以高时空分辨率观察 RNA 的工具。在这里，我们回顾了 RNA 成像的最新进展，并强调了它们将如何推动 RNA 生物学领域的发展。我们讨论了 RNA 成像的当前趋势及其阐明 RNA 生物学中未解决问题的潜力。
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