成人大脑原发性脑出血后的神经发生
Neurogenesis after primary intracerebral hemorrhage in adult human brain.
作者信息
Shen Jianfeng, Xie Lin, Mao XiaoOu, Zhou Yongqing, Zhan Renya, Greenberg David A, Jin Kunlin
机构信息
Department of Neurosurgery, First Affiliated Hospital, Zhejiang University College of Medicine, Zhejiang, China.
出版信息
J Cereb Blood Flow Metab. 2008 Aug;28(8):1460-8. doi: 10.1038/jcbfm.2008.37. Epub 2008 Apr 30.
Abstract
Neurogenesis occurs in discrete regions of normal brains of adult mammals including humans, and is induced in response to brain injury and neurodegenerative disease. Whether intracerebral hemorrhage can also induce neurogenesis in human brain is unknown. Specimens were obtained from patients with primary intracerebral hemorrhage undergoing surgical evacuation of an intracerebral hematoma, and evaluated by two-photon laser scanning confocal microscopy. We found that neural stem/progenitor cell-specific protein markers were expressed in cells located in the perihematomal regions of the basal ganglia and parietal lobe of the adult human brain after primary intracerebral hemorrhage (n=5). Cells in this region also expressed cell proliferation markers, which colocalized to the same cells that expressed neural stem/progenitor cell-specific proteins. Our data suggest that intracerebral hemorrhage induces neurogenesis in the adult human brain.
摘要
神经发生存在于包括人类在内的成年哺乳动物正常大脑的离散区域，并在脑损伤和神经退行性疾病的刺激下被诱导产生。脑出血是否也能在人类大脑中诱导神经发生尚不清楚。我们从接受脑内血肿手术清除的原发性脑出血患者身上获取标本，并通过双光子激光扫描共聚焦显微镜进行评估。我们发现，在原发性脑出血后的成年人类大脑基底节和顶叶血肿周围区域的细胞中，表达了神经干细胞/祖细胞特异性蛋白标记物（n = 5）。该区域的细胞还表达了细胞增殖标记物，这些标记物与表达神经干细胞/祖细胞特异性蛋白的细胞共定位。我们的数据表明，脑出血可在成年人类大脑中诱导神经发生。
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本文引用的文献
1
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Brain Res. 2007 Dec 5;1183:43-50. doi: 10.1016/j.brainres.2007.09.005. Epub 2007 Sep 14.
2
Increase in neurogenesis and neuroblast migration after a small intracerebral hemorrhage in rats.大鼠小脑出血后神经发生及神经母细胞迁移增加。
Neurosci Lett. 2007 Sep 25;425(2):114-9. doi: 10.1016/j.neulet.2007.08.039. Epub 2007 Aug 25.
3
Widespread cellular proliferation and focal neurogenesis after traumatic brain injury in the rat.大鼠创伤性脑损伤后广泛的细胞增殖和局灶性神经发生。
Restor Neurol Neurosci. 2007;25(1):65-76.
4
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5
Brain transplantation of immortalized human neural stem cells promotes functional recovery in mouse intracerebral hemorrhage stroke model.永生化人类神经干细胞的脑移植促进小鼠脑出血中风模型的功能恢复。
Stem Cells. 2007 May;25(5):1204-12. doi: 10.1634/stemcells.2006-0409. Epub 2007 Jan 11.
6
A neurovascular niche for neurogenesis after stroke.中风后神经发生的神经血管微环境。
J Neurosci. 2006 Dec 13;26(50):13007-16. doi: 10.1523/JNEUROSCI.4323-06.2006.
7
Evidence for stroke-induced neurogenesis in the human brain.人类大脑中中风诱导神经发生的证据。
Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13198-202. doi: 10.1073/pnas.0603512103. Epub 2006 Aug 21.
8
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9
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Neurol Res. 2006 Jan;28(1):104-12. doi: 10.1179/016164106X91960.
10
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Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18189-94. doi: 10.1073/pnas.0506375102. Epub 2005 Dec 2.
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