Croce C M
Proc Natl Acad Sci U S A. 1976 Sep;73(9):3248-52. doi: 10.1073/pnas.73.9.3248.
Somatic cell hybrids between mouse peritioneal macrophages and HT-1080 human fibrosarcoma cells lose mouse chromosomes and retain the entire complement of human chromosomes. In contrast, somatic cell hybrids between cells derived from two different mouse continuous cell lines and HT-1080 human cells were found to lose human chromosomes preferentially. Loss of mouse chromosomes is not a general property of hybrids between mouse macrophages and transformed human cells; the hybridization of mouse macrophages with cells derived from five different human fibroblast lines transformed by simian virus 40 resulted in the production of hybrid clones that preferentially lost human chromosomes.
小鼠腹膜巨噬细胞与HT - 1080人纤维肉瘤细胞之间的体细胞杂种会丢失小鼠染色体，并保留完整的人类染色体组。相比之下，来自两种不同小鼠连续细胞系的细胞与HT - 1080人细胞之间的体细胞杂种则优先丢失人类染色体。小鼠染色体的丢失并非小鼠巨噬细胞与转化人细胞之间杂种的普遍特性；小鼠巨噬细胞与由猿猴病毒40转化的五种不同人成纤维细胞系来源的细胞杂交，产生的杂交克隆优先丢失人类染色体。
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