Hommel Marcel
Institut Pasteur, 25-28, rue du Docteur Roux, 75724 Paris cedex.
Bull Acad Natl Med. 2007 Oct;191(7):1235-45; discussion 1245-6.
Laveran first discovered that an infectious agent was responsible for malaria by using a simple microscope, without the assistance of specific stains. Our knowledge of the Plasmodium life cycle and cellular biology has progressed with each technological advance, from Romanovsky staining and histology to electron microscopy, immunocytochemistry, molecular methods and modern imaging techniques. The use of bird, primate and rodent models also made a major contribution, notably in the development of antimalarial drugs that are still in use today.
拉韦朗首次通过使用一台简单显微镜发现一种感染因子是疟疾的病因，当时没有特定染色剂的辅助。随着每一项技术进步，我们对疟原虫生命周期和细胞生物学的认识不断发展，从罗曼诺夫斯基染色法和组织学到电子显微镜、免疫细胞化学、分子方法以及现代成像技术。鸟类、灵长类和啮齿类动物模型的使用也做出了重大贡献，特别是在当今仍在使用的抗疟药物的研发方面。
