Amagase Harunobu, Nance Dwight M
FreeLife International, LLC, Phoenix, AZ 85040, USA.
J Altern Complement Med. 2008 May;14(4):403-12. doi: 10.1089/acm.2008.0004.
This randomized, double-blind, placebo-controlled clinical trial is the first study reported from outside China that has examined the general effects of the orally consumed goji berry, Lycium barbarum, as a standardized juice (GoChi; FreeLife International LLC, Phoenix, AZ) to healthy adults for 14 days.
Based upon the medicinal properties of Lycium barbarum in traditional Asian medicine, we examined by questionnaire subjective ratings (0-5) of general feelings of well-being, neurologic/psychologic traits, gastrointestinal, musculoskeletal, and cardiovascular complaints as well as any adverse effects. Also, measures of body weight, body-mass index, blood pressure, pulse rate, and visual acuity were assessed before and after consuming 120 mL of GoChi/day or placebo control solution. Data were statistically analyzed for changes between day 1 and day 15.
Significant differences between day 1 and day 15 were found in the GoChi group (N = 16) in increased ratings for energy level, athletic performance, quality of sleep, ease of awakening, ability to focus on activities, mental acuity, calmness, and feelings of health, contentment, and happiness. GoChi also significantly reduced fatigue and stress, and improved regularity of gastrointestinal function. In contrast, the placebo group (N = 18) showed only two significant changes (heartburn and happiness). No significant changes in musculoskeletal or cardiovascular complaints were observed in either group. All parametric data (body weight, etc.) were not significantly different between groups or between day 1 and day 15 for either group.
These results clearly indicate that daily consumption of GoChi for 14 days increases subjective feelings of general well-being, and improves neurologic/psychologic performance and gastrointestinal functions. The data strongly suggest that further research is indicated to confirm and extend knowledge of the potential effects of Lycium barbarum upon human health.
这项随机、双盲、安慰剂对照临床试验是中国境外报道的第一项研究，该研究检测了口服标准化枸杞汁（GoChi；FreeLife International LLC，亚利桑那州凤凰城）对健康成年人14天的总体影响。
基于枸杞在传统亚洲医学中的药用特性，我们通过问卷调查主观评分（0 - 5）来评估总体幸福感、神经/心理特征、胃肠道、肌肉骨骼和心血管方面的不适以及任何不良反应。此外，在每天饮用120 mL GoChi或安慰剂对照溶液前后，测量体重、体重指数、血压、脉搏率和视力。对第1天和第15天之间的变化进行了统计分析。
GoChi组（N = 16）在第1天和第15天之间发现了显著差异，能量水平、运动表现、睡眠质量、易唤醒程度、专注于活动的能力、思维敏锐度、平静程度以及健康、满足和幸福感的评分有所提高。GoChi还显著减轻了疲劳和压力，并改善了胃肠功能的规律性。相比之下，安慰剂组（N = 18）仅出现了两个显著变化（胃灼热和幸福感）。两组在肌肉骨骼或心血管方面的不适均未观察到显著变化。所有参数数据（体重等）在两组之间或每组的第1天和第15天之间均无显著差异。
这些结果清楚地表明，连续14天每天饮用GoChi可增加总体幸福感的主观感受，并改善神经/心理表现和胃肠功能。数据强烈表明，需要进一步研究以确认和扩展枸杞对人类健康潜在影响的认识。
