Epidemiology & Biostatistics, College of Public Health, University of Arizona, Tucson, Arizona, USA.
J Med Food. 2012 Nov;15(11):1006-14. doi: 10.1089/jmf.2012.0013. Epub 2012 Aug 16.
Four randomized, blind, placebo-controlled clinical trials were pooled to study the general effects of oral consumption of Lycium barbarum at 120 mL/day, as a standardized juice, GoChi(®) (FreeLife International, Phoenix, AZ, USA). A questionnaire consisting of symptoms graded 0-5 was given to the participants. For each question, the score changes in the questionnaire between pre- and postintervention were summarized by the standardized mean difference and associated SE to perform the meta-analysis. The change was also characterized into a binary outcome, improved or not, to derive odds ratio (OR) and associated SE derived by a binary outcome using the Mantel-Haenszel method. The meta-analysis and heterogeneity were evaluated with the R program using the rmeta package. Statistical significance was set at 5%. In total, 161 participants (18-72 years old) were included in the meta-analysis. Compared with the placebo group (n=80), the active group (n=81) showed significant improvements in weakness, stress, mental acuity, ease of awakening, shortness of breath, focus on activity, sleep quality, daydreaming, and overall feelings of health and well-being under a random effects model. A fixed effects model showed additional improvements in fatigue, depression, circulation, and calmness. The OR indicated significantly higher chance to improve fatigue, dizziness, and sleep quality. Three studies had statistically significant heterogeneity in procrastination, shoulder stiffness, energy, and calmness. The present meta-analysis confirmed the various health effects of L. barbarum polysaccharides-standardized L. barbarum intake found in the previous randomized, double-blind, placebo-controlled human clinical trials and revealed it resulted in statistically significant improvements in neurological/psychological performance and overall feelings of health and well-being compared with the placebo group under both the fixed and the random effects models of the R program.
四项随机、双盲、安慰剂对照的临床试验被汇总，以研究每天口服 120 毫升标准化枸杞汁 GoChi(®)（美国凤凰城 FreeLife International）对一般健康的影响。参与者填写了一份症状评分 0-5 的问卷。对于每个问题，使用标准化均数差值和相关 SE 总结干预前后问卷评分的变化，以进行荟萃分析。变化也被描述为二进制结果（改善或未改善），使用 Mantel-Haenszel 方法得出二项结果的比值比（OR）和相关 SE。荟萃分析和异质性使用 R 程序和 rmeta 包进行评估。统计显著性设定为 5%。共有 161 名参与者（18-72 岁）被纳入荟萃分析。与安慰剂组（n=80）相比，活性组（n=81）在疲劳、压力、思维敏捷、易醒、呼吸急促、注意力集中、睡眠质量、白日梦和整体健康和幸福感方面，表现出显著的改善，在随机效应模型下。固定效应模型显示疲劳、抑郁、循环和镇静方面有额外的改善。OR 表明改善疲劳、头晕和睡眠质量的机会显著增加。三项研究在拖延、肩部僵硬、能量和镇静方面具有统计学上的显著异质性。本荟萃分析证实了先前随机、双盲、安慰剂对照的人体临床试验中发现的枸杞多糖标准化枸杞摄入的各种健康影响，并显示与安慰剂组相比，它在 R 程序的固定和随机效应模型下均导致神经/心理表现和整体健康和幸福感的统计学显著改善。
