Geisser Michael E, Strader Donnell Cathy, Petzke Frank, Gracely Richard H, Clauw Daniel J, Williams David A
Chronic Pain and Fatigue Research Center, Dept. of Internal Medicine, Div. of Rheumatology, Univ. of Michigan, Ann Arbor, MI 48108, USA.
Psychosomatics. 2008 May-Jun;49(3):235-42. doi: 10.1176/appi.psy.49.3.235.
Somatic symptoms are common in conditions such as fibromyalgia (FM) and chronic fatigue syndrome (CFS).
Authors investigated a potential shared pathologic mechanism: a generalized perceptual abnormality where there is heightened responsiveness to varied sensory stimulation, including pain.
A composite measure of sensory sensitivity was created and compared with measures of somatic symptoms, comorbid psychological disturbances, and self-reported physical functioning in 38 patients with FM and/or CFS.
Sensory amplification influenced physical functioning indirectly through pain intensity, and physical symptoms and fatigue also independently contributed to physical functioning.
Sensory amplification may be an underlying pathophysiologic mechanism in these disorders that is relatively independent of depression and depressive symptoms.
躯体症状在纤维肌痛（FM）和慢性疲劳综合征（CFS）等病症中很常见。
作者研究了一种潜在的共同病理机制：一种普遍的感知异常，即对包括疼痛在内的各种感觉刺激反应增强。
创建了一种感觉敏感性的综合测量方法，并将其与38例FM和/或CFS患者的躯体症状、共病心理障碍及自我报告的身体功能测量结果进行比较。
感觉放大通过疼痛强度间接影响身体功能，身体症状和疲劳也独立地影响身体功能。
感觉放大可能是这些疾病相对独立于抑郁和抑郁症状的潜在病理生理机制。
