Wehner Astrid, Hartmann Katrin, Hirschberger Johannes
Department of Small Animal Internal Medicine, Faculty of Veterinary Medicine, Ludwig Maximilians University Munich, Munich, Germany 80539.
J Am Anim Hosp Assoc. 2008 May-Jun;44(3):131-8. doi: 10.5326/0440131.
A human kit for cystatin C determination was evaluated for use with canine sera. A reference range was also established. The association between cystatin C and glomerular filtration rate (GFR) was evaluated in 60 dogs with various diseases, by using exogenous creatinine plasma clearance (ECPC) as a measure of GFR. The correlation between cystatin C and ECPC (correlation coefficient [r] = -0.630; P<0.001) was stronger than the correlation between serum creatinine and ECPC (r = -0.572; P<0.001). Nonrenal diseases (e.g., neoplasia, infection) did not influence serum cystatin C concentration. Test sensitivity was significantly better (P<0.001) for cystatin C (76%) than for creatinine (65%). Specificities for the two tests were 87% and 91%, respectively.
对一种用于测定胱抑素C的人类试剂盒进行了评估，以确定其是否适用于犬血清。还建立了一个参考范围。通过使用外源性肌酐血浆清除率（ECPC）作为肾小球滤过率（GFR）的指标，在60只患有各种疾病的犬中评估了胱抑素C与GFR之间的关联。胱抑素C与ECPC之间的相关性（相关系数[r]=-0.630；P<0.001）比血清肌酐与ECPC之间的相关性（r=-0.572；P<0.001）更强。非肾脏疾病（如肿瘤、感染）不影响血清胱抑素C浓度。胱抑素C的检测灵敏度（76%）显著高于肌酐（65%）（P<0.001）。两种检测方法的特异性分别为87%和91%。
