Urzúa Alejandro, Rezende Marcos C, Mascayano Carolina, Vásquez Loretta
Facultad de Química y Biología, Casilla 40, Correo 33, Universidad de Santiago de Chile, Santiago, Chile.
Molecules. 2008 Apr 17;13(4):882-91. doi: 10.3390/molecules13040822.
An analysis of the antibacterial activities of 15 terpenoids, eleven of which were previously described by us and four were extracted from the literature, suggested two structural requirements for activity of these and related compounds: a hydrophobic moiety,consisting of a substituted decalin skeleton, and a hydrophilic region possessing one hydrogen-bond-donor group. These structural requirements are responsible for an optimal insertion of these and related compounds into cell membranes, as suggested by the results of docking some of these compounds into a model phospholipid bilayer.
对15种萜类化合物的抗菌活性进行分析，其中11种是我们之前描述过的，4种是从文献中提取的，结果表明这些化合物及相关化合物具有活性的两个结构要求：一个由取代十氢化萘骨架组成的疏水部分，以及一个含有一个氢键供体基团的亲水区域。正如将其中一些化合物对接至模型磷脂双层的结果所示，这些结构要求有助于这些化合物及相关化合物最佳地插入细胞膜。
