局部脂肪组织肾素-血管紧张素系统
Local adipose tissue renin-angiotensin system.
作者信息
Cassis Lisa A, Police Sara B, Yiannikouris Frederique, Thatcher Sean E
机构信息
Graduate Center for Nutritional Sciences, Wethington Building, Room 521b, 900 South Limestone Street, University of Kentucky, Lexington, KY 40536-0200, USA.
出版信息
Curr Hypertens Rep. 2008 Apr;10(2):93-8. doi: 10.1007/s11906-008-0019-9.
Abstract
A local renin-angiotensin system (RAS) has been proposed in adipocytes. Adipocytes are a suggested source of components of the RAS, with regulation of their production related to obesity-hypertension. Both angiotensin type 1 and 2 receptors have been localized to adipocytes. Angiotensin II has been demonstrated to regulate adipocyte growth and differentiation, lipid metabolism, and expression and release of adipokines and RAS components, and to promote oxidative stress. Differences in regional expression of RAS components in visceral versus subcutaneous adipose tissue have been suggested as a link between abdominal obesity and cardiovascular disease. Finally, several studies support antihypertensive efficacy of RAS blockade in patients with type 2 diabetes and obesity. Future studies should address the role of adipocyte-specific deficiency of RAS components to definitively determine the relevance of the adipose RAS to normal physiology and to the development of hypertension.
摘要
脂肪细胞中已提出存在局部肾素-血管紧张素系统（RAS）。脂肪细胞被认为是RAS组分的一个来源，其产生的调节与肥胖相关性高血压有关。1型和2型血管紧张素受体均已在脂肪细胞中定位。已证实血管紧张素II可调节脂肪细胞的生长和分化、脂质代谢以及脂肪因子和RAS组分的表达与释放，并促进氧化应激。内脏脂肪组织与皮下脂肪组织中RAS组分的区域表达差异被认为是腹部肥胖与心血管疾病之间的一个联系。最后，多项研究支持RAS阻断剂对2型糖尿病和肥胖患者的降压疗效。未来的研究应探讨脂肪细胞特异性缺乏RAS组分的作用，以明确确定脂肪RAS与正常生理以及高血压发生发展的相关性。
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