Gosse Philippe, Roche Frederic, Dauphinot Virginie, Maudoux Delphine, Pichot Vincent, Barthelemy Jean Claude
Saint André Hospital, University Hospital of Bordeaux, Bordeaux, France.
J Hypertens. 2008 Jun;26(6):1138-46. doi: 10.1097/HJH.0b013e3282fa142b.
Arterial stiffness increases with age, diabetes and hypertension, and is linked to the occurrence of cardiovascular complications, independently of traditional risk factors. The important influence of age and blood pressure on arterial stiffness and cardiovascular risk complicates analysis of factors involved in increased arterial stiffness. Study of the PROOF cohort supplied further information by analysis of subjects of identical age using a method that eliminates the immediate influence of blood pressure on pulse wave velocity.
The PROOF cohort comprised 1011 subjects, aged 65 years, from the city of Saint-Etienne (France). All benefited from 24-h ambulatory blood pressure monitoring coupled with measurement of QKD interval. Ambulatory Arterial Stiffness Index and QKD(100-60), were calculated for each recording. Measurements were performed again 2 years later.
Height-predicted QKD(100-60) was correlated with pulse pressure and the presence of diabetes. We found no significant influence of sex, current smoking or total serum cholesterol. Ambulatory Arterial Stiffness Index, whether it was height predicted or not, only had a significant relationship with blood pressure. Two years later, although the QKD(100-60) remained stable for the overall population, it was reduced in the normotensive subjects. Over the whole population, there was a correlation between the changes in 24-h systolic blood pressure and QKD(100-60).
QKD(100-60), an isobaric index of arterial stiffness, is significantly linked to blood pressure and blood sugar levels in a population of 65-year-old subjects. Two years later, the arterial stiffness increased significantly in the normotensive subjects, whereas it remained stable in the hypertensive subjects.
动脉僵硬度随年龄、糖尿病和高血压增加，且与心血管并发症的发生相关，独立于传统危险因素。年龄和血压对动脉僵硬度及心血管风险的重要影响使参与动脉僵硬度增加的因素分析变得复杂。对PROOF队列的研究通过使用一种消除血压对脉搏波速度直接影响的方法对相同年龄的受试者进行分析，提供了更多信息。
PROOF队列由来自法国圣艾蒂安市的1011名65岁受试者组成。所有人均受益于24小时动态血压监测及QKD间期测量。为每次记录计算动态动脉僵硬度指数和QKD(100 - 60)。2年后再次进行测量。
身高预测的QKD(100 - 60)与脉压及糖尿病的存在相关。我们未发现性别、当前吸烟状况或总血清胆固醇有显著影响。动态动脉僵硬度指数，无论是否根据身高预测，仅与血压有显著关系。2年后，尽管总体人群的QKD(100 - 60)保持稳定，但在血压正常的受试者中降低。在整个人群中，24小时收缩压变化与QKD(100 - 60)之间存在相关性。
QKD(100 - 60)，一种动脉僵硬度的等压指数，在65岁受试者人群中与血压和血糖水平显著相关。2年后，血压正常的受试者动脉僵硬度显著增加，而高血压受试者中则保持稳定。
