Breivik H, Borchgrevink P C, Allen S M, Rosseland L A, Romundstad L, Hals E K Breivik, Kvarstein G, Stubhaug A
Faculty of Medicine, University of Oslo, Oslo, Norway.
Br J Anaesth. 2008 Jul;101(1):17-24. doi: 10.1093/bja/aen103. Epub 2008 May 16.
Valid and reliable assessment of pain is essential for both clinical trials and effective pain management. The nature of pain makes objective measurement impossible. Acute pain can be reliably assessed, both at rest (important for comfort) and during movement (important for function and risk of postoperative complications), with one-dimensional tools such as numeric rating scales or visual analogue scales. Both these are more powerful in detecting changes in pain intensity than a verbal categorical rating scale. In acute pain trials, assessment of baseline pain must ensure sufficient pain intensity for the trial to detect meaningful treatment effects. Chronic pain assessment and its impact on physical, emotional, and social functions require multidimensional qualitative tools and health-related quality of life instruments. Several disease- and patient-specific functional scales are useful, such as the Western Ontario and MacMaster Universities for osteoarthritis, and several neuropathic pain screening tools. The Initiative on
Measurement, and Pain Assessment in Clinical Trials recommendations for outcome measurements of chronic pain trials are also useful for routine assessment. Cancer pain assessment is complicated by a number of other bodily and mental symptoms such as fatigue and depression, all affecting quality of life. It is noteworthy that quality of life reported by chronic pain patients can be as much affected as that of terminal cancer patients. Any assessment of pain must take into account other factors, such as cognitive impairment or dementia, and assessment tools validated in the specific patient groups being studied.
对疼痛进行有效且可靠的评估对于临床试验和有效的疼痛管理都至关重要。疼痛的本质使得客观测量成为不可能。急性疼痛可以通过一维工具,如数字评分量表或视觉模拟量表,在静息时(对舒适度很重要)和运动期间(对功能及术后并发症风险很重要)进行可靠评估。这两种工具在检测疼痛强度变化方面比言语分类评分量表更有效。在急性疼痛试验中,对基线疼痛的评估必须确保有足够的疼痛强度,以便试验能够检测到有意义的治疗效果。慢性疼痛评估及其对身体、情感和社会功能的影响需要多维定性工具和与健康相关的生活质量工具。一些针对疾病和患者的特定功能量表很有用,例如用于骨关节炎的西安大略和麦克马斯特大学骨关节炎指数,以及一些神经性疼痛筛查工具。临床试验中关于慢性疼痛试验结果测量的“测量与疼痛评估倡议”建议对于常规评估也很有用。癌症疼痛评估因疲劳和抑郁等许多其他身体和精神症状而变得复杂,所有这些都会影响生活质量。值得注意的是,慢性疼痛患者报告的生活质量可能与晚期癌症患者的生活质量受到同样程度的影响。任何疼痛评估都必须考虑其他因素,如认知障碍或痴呆,以及在正在研究的特定患者群体中经过验证的评估工具。