Key Laboratory of Analytical Chemistry for Biology and Medicine, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, People's Republic of China.
J Mater Sci Mater Med. 2013 Aug;24(8):1843-51. doi: 10.1007/s10856-013-4954-x. Epub 2013 May 28.
Chitosan-multiwalled carbon nanotubes/hydroxyapatite nanocomposites were synthesized by a novel in situ precipitation method. The electrostatic adsorption between multiwalled carbon nanotubes and chitosan was investigated and explained by Fourier transform infrared spectroscopy analysis. Morphology studies showed that uniform distribution of hydroxyapatite particles and multiwalled carbon nanotubes in the polymer matrix was observed. In chitosan-multiwalled carbon nanotubes/hydroxyapatite nanocomposites, the diameters of multiwalled carbon nanotubes were about 10 nm. The mechanical properties of the composites were evaluated by measuring their compressive strength and elastic modulus. The elastic modulus and compressive strength increased sharply from 509.9 to 1089.1 MPa and from 33.2 to 105.5 MPa with an increase of multiwalled carbon/chitosan weight ratios from 0 to 5 %, respectively. Finally, the cell biocompatibility of the composites was tested in vitro, which showed that they have good biocompatibility. These results suggest that the chitosan-multiwalled carbon nanotubes/hydroxyapatite nanocomposites are promising biomaterials for bone tissue engineering.
壳聚糖-多壁碳纳米管/羟基磷灰石纳米复合材料通过一种新颖的原位沉淀法合成。通过傅里叶变换红外光谱分析研究并解释了多壁碳纳米管和壳聚糖之间的静电吸附作用。形貌研究表明，在聚合物基体中观察到羟基磷灰石颗粒和多壁碳纳米管的均匀分布。在壳聚糖-多壁碳纳米管/羟基磷灰石纳米复合材料中，多壁碳纳米管的直径约为 10nm。通过测量复合材料的抗压强度和弹性模量来评估其力学性能。随着多壁碳/壳聚糖重量比从 0 增加到 5%，弹性模量和抗压强度分别从 509.9MPa 急剧增加到 1089.1MPa 和从 33.2MPa 增加到 105.5MPa。最后，体外测试了复合材料的细胞生物相容性，结果表明它们具有良好的生物相容性。这些结果表明，壳聚糖-多壁碳纳米管/羟基磷灰石纳米复合材料有望成为骨组织工程的生物材料。
