Int J Cardiol. 2009 May 29;134(3):e124-5. doi: 10.1016/j.ijcard.2008.01.029. Epub 2008 May 22.
Cardiac syndrome X is defined by an angina pectoris with normal or near normal coronary angiogram.We evaluated the association of Helicobacter pylori (HP) infection with cardiac syndrome X (CSX). We studied 30 patients with CSX, 30 cases with stable angina and also 30 healthy controls. All three groups underwent urea breath test (UBT). Fifty percent (15 out of 30) of CSX patients had positive UBT result (> or =200 dpm), while two other groups did not have the positive results. Regarding high prevalence of HP infection in patients with CSX in our study and probable causative effect of chronic infection in coronary artery diseases, possible role of HP infection in the pathogenesis of CSX is suggested. However well designed clinical trial studies are needed to confirm this preliminary result.
心脏 X 综合征是指心绞痛伴有正常或近乎正常的冠状动脉造影。我们评估了幽门螺杆菌（HP）感染与心脏 X 综合征（CSX）的关系。我们研究了 30 例 CSX 患者、30 例稳定性心绞痛患者和 30 例健康对照组。所有三组均进行尿素呼气试验（UBT）。50%（30 例中的 15 例）CSX 患者 UBT 结果阳性（>或=200dpm），而另外两组则没有阳性结果。鉴于本研究中 CSX 患者 HP 感染的高患病率以及慢性感染对冠状动脉疾病的可能因果作用，提示 HP 感染可能在 CSX 的发病机制中起作用。然而，需要进行精心设计的临床试验研究来证实这一初步结果。
