Eskandarian R, Malek M, Mousavi S H, Babaei M
Internal Medicine Research Centre, Fatemieh Hospital, Semnan University of Medical Sciences, Semnan, Iran.
Singapore Med J. 2006 Aug;47(8):704-6.
Cardiac syndrome X (CSX) includes chest pain, positive exercise stress test and/or radionuclide test for ischaemia and normal coronary angiography. There is no obvious aetiology for this syndrome. Some mechanisms such as endothelial dysfunction and oestrogen deficiency have been invoked. In this study, we surveyed the association of Helicobacter pylori (HP) infection with cardiac syndrome X.
HP infection was detected by urea breath test (UBT) in patients with cardiac syndrome X, and compared with a sex- and age-matched control group. Patients with dyspepsia and coronary spasm were excluded. Statistical analysis was carried out using chi-square test.
40 patients (29 females and 11 males) with cardiac syndrome X aged between 30 and 65 years (mean 45.51 +/- 5.03 years) were compared with a control group (28 females and 12 males) aged between 31 and 64 years old (mean 44.93 +/- 5.16 years). 95 percent of patients were HP infected, while only 47.5 percent of members of the control group were infected (p-value is less than 0.001).
Considering the high prevalence of HP infection in patients with CSX in our sample and probable causative effect of chronic infection in vascular diseases, we believe that there is a probable role for HP infection in the pathogenesis of CSX.
心脏X综合征（CSX）包括胸痛、运动负荷试验和/或放射性核素缺血试验阳性以及冠状动脉造影正常。该综合征尚无明显病因。已提出一些机制，如内皮功能障碍和雌激素缺乏。在本研究中，我们调查了幽门螺杆菌（HP）感染与心脏X综合征的关联。
通过尿素呼气试验（UBT）检测心脏X综合征患者的HP感染情况，并与性别和年龄匹配的对照组进行比较。排除消化不良和冠状动脉痉挛患者。采用卡方检验进行统计分析。
将40例年龄在30至65岁（平均45.51±5.03岁）的心脏X综合征患者（29例女性和11例男性）与对照组（28例女性和12例男性）进行比较，对照组年龄在31至64岁（平均44.93±5.16岁）。95%的患者感染了HP，而对照组只有47.5%的成员感染（p值小于0.001）。
考虑到我们样本中CSX患者HP感染的高患病率以及慢性感染在血管疾病中可能的致病作用，我们认为HP感染在CSX的发病机制中可能起作用。
