Banga Julio R
Instituto de Investigaciones Marinas, CSIC (Spanish Council for Scientific Research), C/Eduardo Cabello 6, 36208 Vigo, Spain.
BMC Syst Biol. 2008 May 28;2:47. doi: 10.1186/1752-0509-2-47.
Optimization aims to make a system or design as effective or functional as possible. Mathematical optimization methods are widely used in engineering, economics and science. This commentary is focused on applications of mathematical optimization in computational systems biology. Examples are given where optimization methods are used for topics ranging from model building and optimal experimental design to metabolic engineering and synthetic biology. Finally, several perspectives for future research are outlined.
优化旨在使系统或设计尽可能有效或具备功能。数学优化方法在工程、经济和科学领域被广泛应用。本评论聚焦于数学优化在计算系统生物学中的应用。文中给出了一些例子，展示了优化方法在从模型构建、最优实验设计到代谢工程和合成生物学等一系列主题中的应用。最后，概述了未来研究的几个方向。
