Payungporn Sunchai, Crawford P Cynda, Kouo Theodore S, Chen Li-mei, Pompey Justine, Castleman William L, Dubovi Edward J, Katz Jacqueline M, Donis Ruben O
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
Emerg Infect Dis. 2008 Jun;14(6):902-8. doi: 10.3201/eid1406.071270.
In 2004, canine influenza virus subtype H3N8 emerged in greyhounds in the United States. Subsequent serologic evidence indicated virus circulation in dog breeds other than greyhounds, but the virus had not been isolated from affected animals. In 2005, we conducted virologic investigation of 7 nongreyhound dogs that died from respiratory disease in Florida and isolated influenza subtype H3N8 virus. Antigenic and genetic analysis of A/canine/Jacksonville/2005 (H3N8) and A/canine/Miami/2005 (H3N8) found similarity to earlier isolates from greyhounds, which indicates that canine influenza viruses are not restricted to greyhounds. The hemagglutinin contained 5 conserved amino acid differences that distinguish canine from equine lineages. The antigenic homogeneity of the canine viruses suggests that measurable antigenic drift has not yet occurred. Continued surveillance and antigenic analyses should monitor possible emergence of antigenic variants of canine influenza virus.
2004年，H3N8亚型犬流感病毒在美国灵缇犬中出现。随后的血清学证据表明该病毒在灵缇犬以外的犬种中传播，但尚未从受感染动物中分离出该病毒。2005年，我们对佛罗里达州7只因呼吸道疾病死亡的非灵缇犬进行了病毒学调查，并分离出H3N8亚型流感病毒。对A/犬/杰克逊维尔/2005（H3N8）和A/犬/迈阿密/2005（H3N8）进行的抗原和基因分析发现，它们与早期从灵缇犬分离出的毒株相似，这表明犬流感病毒并不局限于灵缇犬。血凝素含有5个保守的氨基酸差异，可将犬系与马系区分开来。犬病毒的抗原同质性表明尚未发生可检测到的抗原漂移。持续的监测和抗原分析应监测犬流感病毒抗原变异体的可能出现。
